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Alkylating potential of styrene oxide: reactions and factors involved in the alkylation process

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URI: https://hdl.handle.net/10016/31876
ISSN: 0893-228X
DOI: https://doi.org/10.1021/tx5002892
UXXI: AR/0000016394
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alkylating_CRT_2014_ps.pdf (470.09 KB)
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2014-09-15
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American Chemical Society
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Abstract
The chemical reactivity of styrene-7,8-oxide (SO), an alkylating agent with high affinity for the guanine-N7 position and a probable carcinogen for humans, with 4-(p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to those of DNA bases, was investigated kinetically in water/dioxane media. UV-vis spectrophotometry and ultrafast liquid chromatography were used to monitor the reactions involved...
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Alcohols, Adducts, Kinetic parameters, Hydrolysis, Post-translational modification
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Chemical Research in Toxicology, (2014), 27(10), pp.: 1853–1859.
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