Alkylating potential of styrene oxide: reactions and factors involved in the alkylation process

Research Projects
Organizational Units
Journal Issue
The chemical reactivity of styrene-7,8-oxide (SO), an alkylating agent with high affinity for the guanine-N7 position and a probable carcinogen for humans, with 4-(p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to those of DNA bases, was investigated kinetically in water/dioxane media. UV-vis spectrophotometry and ultrafast liquid chromatography were used to monitor the reactions involved...
Alcohols, Adducts, Kinetic parameters, Hydrolysis, Post-translational modification
Bibliographic citation
Chemical Research in Toxicology, (2014), 27(10), pp.: 1853–1859.