Publication: Alkylating potential of styrene oxide: reactions and factors involved in the alkylation process
dc.affiliation.dpto | UC3M. Departamento de Ciencia e Ingeniería de Materiales e Ingeniería Química | es |
dc.affiliation.grupoinv | UC3M. Grupo de Investigación: Síntesis y Procesado de Materiales | es |
dc.contributor.author | González Pérez, Marina | |
dc.contributor.author | Gómez Bombarelli, Rafael | |
dc.contributor.author | Pérez Prior, María Teresa | |
dc.contributor.author | Arenas Valgañón, Jorge | |
dc.contributor.author | García Santos, María Pilar | |
dc.contributor.author | Calle, Emilio | |
dc.contributor.author | Casado, Julio | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es |
dc.date.accessioned | 2021-02-08T10:48:12Z | |
dc.date.available | 2021-02-08T10:48:12Z | |
dc.date.issued | 2014-09-15 | |
dc.description.abstract | The chemical reactivity of styrene-7,8-oxide (SO), an alkylating agent with high affinity for the guanine-N7 position and a probable carcinogen for humans, with 4-(p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to those of DNA bases, was investigated kinetically in water/dioxane media. UV-vis spectrophotometry and ultrafast liquid chromatography were used to monitor the reactions involved... | en |
dc.description.sponsorship | Thanks are given to the Spanish Ministerio de Economía y Competitividad and the European Regional Development Fund (Project CTQ2010-18999) for supporting the research reported in this article. M.G.-P. and J.A.-V. thank the Junta de Castilla y León-FEDER Funds for Ph.D. grants, and R.G.-B. thanks the Spanish Ministerio de Educación for a Ph.D. fellowship. | en |
dc.description.status | Publicado | es |
dc.format.extent | 6 | |
dc.identifier.bibliographicCitation | Chemical Research in Toxicology, (2014), 27(10), pp.: 1853–1859. | en |
dc.identifier.doi | https://doi.org/10.1021/tx5002892 | |
dc.identifier.issn | 0893-228X | |
dc.identifier.publicationfirstpage | 1853 | |
dc.identifier.publicationissue | 10 | |
dc.identifier.publicationlastpage | 1859 | |
dc.identifier.publicationtitle | CHEMICAL RESEARCH IN TOXICOLOGY | en |
dc.identifier.publicationvolume | 27 | |
dc.identifier.uri | https://hdl.handle.net/10016/31876 | |
dc.identifier.uxxi | AR/0000016394 | |
dc.language.iso | eng | en |
dc.publisher | American Chemical Society | en |
dc.relation.projectID | Gobierno de España. CTQ2010-18999 | es |
dc.rights | © 2014 American Chemical Society. | en |
dc.rights.accessRights | open access | en |
dc.subject.eciencia | Materiales | es |
dc.subject.other | Alcohols | en |
dc.subject.other | Adducts | en |
dc.subject.other | Kinetic parameters | en |
dc.subject.other | Hydrolysis | en |
dc.subject.other | Post-translational modification | en |
dc.title | Alkylating potential of styrene oxide: reactions and factors involved in the alkylation process | en |
dc.type | research article | * |
dc.type.hasVersion | AM | * |
dspace.entity.type | Publication |
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