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Alkylating potential of styrene oxide: reactions and factors involved in the alkylation process

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dc.affiliation.dptoUC3M. Departamento de Ciencia e Ingeniería de Materiales e Ingeniería Químicaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Síntesis y Procesado de Materialeses
dc.contributor.authorGonzález Pérez, Marina
dc.contributor.authorGómez Bombarelli, Rafael
dc.contributor.authorPérez Prior, María Teresa
dc.contributor.authorArenas Valgañón, Jorge
dc.contributor.authorGarcía Santos, María Pilar
dc.contributor.authorCalle, Emilio
dc.contributor.authorCasado, Julio
dc.contributor.funderMinisterio de Economía y Competitividad (España)es
dc.date.accessioned2021-02-08T10:48:12Z
dc.date.available2021-02-08T10:48:12Z
dc.date.issued2014-09-15
dc.description.abstractThe chemical reactivity of styrene-7,8-oxide (SO), an alkylating agent with high affinity for the guanine-N7 position and a probable carcinogen for humans, with 4-(p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to those of DNA bases, was investigated kinetically in water/dioxane media. UV-vis spectrophotometry and ultrafast liquid chromatography were used to monitor the reactions involved...en
dc.description.sponsorshipThanks are given to the Spanish Ministerio de Economía y Competitividad and the European Regional Development Fund (Project CTQ2010-18999) for supporting the research reported in this article. M.G.-P. and J.A.-V. thank the Junta de Castilla y León-FEDER Funds for Ph.D. grants, and R.G.-B. thanks the Spanish Ministerio de Educación for a Ph.D. fellowship.en
dc.description.statusPublicadoes
dc.format.extent6
dc.identifier.bibliographicCitationChemical Research in Toxicology, (2014), 27(10), pp.: 1853–1859.en
dc.identifier.doihttps://doi.org/10.1021/tx5002892
dc.identifier.issn0893-228X
dc.identifier.publicationfirstpage1853
dc.identifier.publicationissue10
dc.identifier.publicationlastpage1859
dc.identifier.publicationtitleCHEMICAL RESEARCH IN TOXICOLOGYen
dc.identifier.publicationvolume27
dc.identifier.urihttps://hdl.handle.net/10016/31876
dc.identifier.uxxiAR/0000016394
dc.language.isoengen
dc.publisherAmerican Chemical Societyen
dc.relation.projectIDGobierno de España. CTQ2010-18999es
dc.rights© 2014 American Chemical Society.en
dc.rights.accessRightsopen accessen
dc.subject.ecienciaMaterialeses
dc.subject.otherAlcoholsen
dc.subject.otherAdductsen
dc.subject.otherKinetic parametersen
dc.subject.otherHydrolysisen
dc.subject.otherPost-translational modificationen
dc.titleAlkylating potential of styrene oxide: reactions and factors involved in the alkylation processen
dc.typeresearch article*
dc.type.hasVersionAM*
dspace.entity.typePublication
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