RT Journal Article
T1 Alkylating potential of styrene oxide: reactions and factors involved in the alkylation process
A1 González Pérez, Marina
A1 Gómez Bombarelli, Rafael
A1 Pérez Prior, María Teresa
A1 Arenas Valgañón, Jorge
A1 García Santos, María Pilar
A1 Calle, Emilio
A1 Casado, Julio
AB The chemical reactivity of styrene-7,8-oxide (SO), an alkylating agent with high affinity for the guanine-N7 position and a probable carcinogen for humans, with 4-(p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to those of DNA bases, was investigated kinetically in water/dioxane media. UV-vis spectrophotometry and ultrafast liquid chromatography were used to monitor the reactions involved...
PB American Chemical Society
SN 0893-228X
YR 2014
FD 2014-09-15
LK https://hdl.handle.net/10016/31876
UL https://hdl.handle.net/10016/31876
LA eng
NO Thanks are given to the Spanish Ministerio de Economía y Competitividad and the European Regional Development Fund (Project CTQ2010-18999) for supporting the research reported in this article. M.G.-P. and J.A.-V. thank the Junta de Castilla y León-FEDER Funds for Ph.D. grants, and R.G.-B. thanks the Spanish Ministerio de Educación for a Ph.D. fellowship.
DS e-Archivo
RD 1 sept. 2024