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Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma

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URI: https://hdl.handle.net/10016/38762
ISSN: 1949-2553
DOI: https://doi.org/10.18632/oncotarget.11370
UXXI: AR/0000018454
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Deregulated_O_2016.pdf (10.22 MB)
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2016-08-18
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Impact Journals
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Abstract
In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification.
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T-cell lymphoblastic lymphoma, Fas-associated death domain protein (FADD), Expression and phosphorylation, Tumor aggressiveness, Prognostic marker
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Marín-Rubio, J. L., Arriba, M., Cobos-Fernández, M. Á., González-Sánchez, L., Ors, I., Sastre, I., Fernández‐Piqueras, J., & Villa‐Morales, M. (2016). Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma. Oncotarget, 7(38), 61485-61499.
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