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Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Tissue Engineering and Regenerative Medicine (TERMeG)es
dc.contributor.authorMarín Rubio, José L.
dc.contributor.authorArriba Pérez, María del Carmen de
dc.contributor.authorCobos Fernández, María A.
dc.contributor.authorGonzález Sánchez, Laura
dc.contributor.authorOrs, Inmaculada
dc.contributor.authorSastre, Isabel
dc.contributor.authorFernández Piqueras, José
dc.contributor.authorVilla Morales, María
dc.contributor.funderComunidad de Madrides
dc.contributor.funderMinisterio de Economía y Competitividad (España)es
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (España)es
dc.date.accessioned2023-11-06T12:38:37Z
dc.date.available2023-11-06T12:38:37Z
dc.date.issued2016-08-18
dc.description.abstractIn the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification.en
dc.description.sponsorshipThis work was supported by grants from Spanish Ministry of Economy and Competitiveness (SAF2015-70561 MINECO/FEDER, UE to JFP/MVM, and SAF2012-36566 to JFP) and Madrid Regional Government (Oncocycle S2011/BMD-2470 to JFP). JLMR is the recipient of a predoctoral fellowship from Spanish Ministry of Education, Culture and Sports (FPU13/00338).en
dc.format.extent15
dc.identifier.bibliographicCitationMarín-Rubio, J. L., Arriba, M., Cobos-Fernández, M. Á., González-Sánchez, L., Ors, I., Sastre, I., Fernández‐Piqueras, J., & Villa‐Morales, M. (2016). Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma. Oncotarget, 7(38), 61485-61499.en
dc.identifier.doihttps://doi.org/10.18632/oncotarget.11370
dc.identifier.issn1949-2553
dc.identifier.publicationfirstpage61485
dc.identifier.publicationissue38
dc.identifier.publicationlastpage61499
dc.identifier.publicationtitleOncotargeten
dc.identifier.publicationvolume7
dc.identifier.urihttps://hdl.handle.net/10016/38762
dc.identifier.uxxiAR/0000018454
dc.language.isoengen
dc.publisherImpact Journalsen
dc.relation.projectIDGobierno de España. SAF2015-70561es
dc.relation.projectIDGobierno de España. SAF2012-3656es
dc.relation.projectIDComunidad de Madrid. S2011/BMD-2470es
dc.relation.projectIDGobierno de España. FPU13/00338es
dc.rights© The Authors, 2016.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaElectrónicaes
dc.subject.ecienciaMedicinaes
dc.subject.otherT-cell lymphoblastic lymphomaen
dc.subject.otherFas-associated death domain protein (FADD)en
dc.subject.otherExpression and phosphorylationen
dc.subject.otherTumor aggressivenessen
dc.subject.otherPrognostic markeren
dc.titleDeregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphomaen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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