RT Journal Article
T1 Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma
A1 Marín Rubio, José L.
A1 Arriba Pérez, María del Carmen de
A1 Cobos Fernández, María A.
A1 González Sánchez, Laura
A1 Ors, Inmaculada
A1 Sastre, Isabel
A1 Fernández Piqueras, José
A1 Villa Morales, María
AB In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification.
PB Impact Journals
SN 1949-2553
YR 2016
FD 2016-08-18
LK https://hdl.handle.net/10016/38762
UL https://hdl.handle.net/10016/38762
LA eng
NO This work was supported by grants from Spanish Ministry of Economy and Competitiveness (SAF2015-70561 MINECO/FEDER, UE to JFP/MVM, and SAF2012-36566 to JFP) and Madrid Regional Government (Oncocycle S2011/BMD-2470 to JFP). JLMR is the recipient of a predoctoral fellowship from Spanish Ministry of Education, Culture and Sports (FPU13/00338).
DS e-Archivo
RD 1 sept. 2024