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Structure and Rheology of Poloxamine T1107 and Its Nanocomposite Hydrogels with Cyclodextrin-Modified Barium Titanate Nanoparticles

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URI: https://hdl.handle.net/10016/31426
ISSN: 0743-7463
DOI: https://doi.org/10.1021/acs.langmuir.6b01544
UXXI: AR/0000018099
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rheology_langmur_2016_ps.pdf (1.61 MB)
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2016-06-28
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ACS Publications
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We report the preparation of a nanocomposite hydrogel based on a poloxamine gel matrix (Tetronic T1107) and cyclodextrin (CD)-modified barium titanate (BT) nanoparticles. The micellization and sol-gel behavior of pH-responsive block copolymer T1107 were fully characterized by small-angle neutron scattering (SANS), dynamic light scattering (DLS), and Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy as a function of concentration, pH and temperature. SANS results reveal that spherical micelles in the low concentration regime present a dehydrated core and highly hydrated shell, with a small aggregation number and size, highly dependent on the degree of protonation of the central amine spacer. At high concentration, T1107 undergoes a sol-gel transition, which is inhibited at acidic pH. Nanocomposites were prepared by incorporating CD-modified BT of two different sizes (50 and 200 nm) in concentrated polymer solutions. Rheological measurements show a broadening of the gel region, as well as an improvement of the mechanical properties, as assessed by the shear elastic modulus, G' (up to 200% increase). Initial cytocompatibility studies of the nanocomposites show that the materials are nontoxic with viabilities over 70% for NIH3T3 fibroblast cell lines. Overall, the combination of Tetronics and modified BaTiO3 provides easily customizable systems with promising applications as soft piezoelectric materials.
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Block copolymers, Graphene oxide, Cancer therapy, Gene delivery, Cell lines, Polymer, Behavior, Gelatin, Biomaterials, Nanocrystals
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Rafael Serra-Gómez, Cécile A. Dreiss, Javier González-Benito, and Gustavo González-Gaitano Langmuir 2016 32 (25), 6398-6408
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