RT Journal Article
T1 Structure and Rheology of Poloxamine T1107 and Its Nanocomposite Hydrogels with Cyclodextrin-Modified Barium Titanate Nanoparticles
A1 Serra Gómez, Rafael
A1 Dreiss, Cecile A.
A1 González Benito, Francisco Javier
A1 Gonzalez Gaitano, Gustavo
AB We report the preparation of a nanocomposite hydrogel based on a poloxamine gel matrix (Tetronic T1107) and cyclodextrin (CD)-modified barium titanate (BT) nanoparticles. The micellization and sol-gel behavior of pH-responsive block copolymer T1107 were fully characterized by small-angle neutron scattering (SANS), dynamic light scattering (DLS), and Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy as a function of concentration, pH and temperature. SANS results reveal that spherical micelles in the low concentration regime present a dehydrated core and highly hydrated shell, with a small aggregation number and size, highly dependent on the degree of protonation of the central amine spacer. At high concentration, T1107 undergoes a sol-gel transition, which is inhibited at acidic pH. Nanocomposites were prepared by incorporating CD-modified BT of two different sizes (50 and 200 nm) in concentrated polymer solutions. Rheological measurements show a broadening of the gel region, as well as an improvement of the mechanical properties, as assessed by the shear elastic modulus, G' (up to 200% increase). Initial cytocompatibility studies of the nanocomposites show that the materials are nontoxic with viabilities over 70% for NIH3T3 fibroblast cell lines. Overall, the combination of Tetronics and modified BaTiO3 provides easily customizable systems with promising applications as soft piezoelectric materials.
PB ACS Publications
SN 0743-7463
YR 2016
FD 2016-06-28
LK https://hdl.handle.net/10016/31426
UL https://hdl.handle.net/10016/31426
LA eng
NO The authors thank ISIS and ILL for the provision of beam timeand R. Heenan (Rutherford Appleton Laboratory), IsabelleGrillo, and E. Larrañeta (Queen’s University Belfast) for theirassistance with the SANS experiments. Prof. G. Martínez deTejada is acknowledged for his invaluable assistance with thecell viability studies. Financial support from projects MAT2014-59116-C2-2-R of the Spanish MINECO is acknowledged. G.G.-G. is grateful to the Vicerrectorado de Relaciones Internacio-nales of the UN for the mobility grant for his sabbatical leave atKCL and Asociación de Amigos of the University of Navarrafor the Ph.D. grant of R. Serra-Gómez.
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RD 1 sept. 2024