Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner

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dc.contributor.author Zingone, A.
dc.contributor.author Seidel, J.
dc.contributor.author Aloj, L.
dc.contributor.author Caraco, C.
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Jagoda, E. M.
dc.contributor.author Chou, J. Y.
dc.contributor.author Green, M. V.
dc.contributor.author Eckelman, W. C.
dc.date.accessioned 2010-10-05T08:38:06Z
dc.date.available 2010-10-05T08:38:06Z
dc.date.issued 2002-08-02
dc.identifier.bibliographicCitation Life Sciences, 2002, vol. 71, n. 11, p. 1293-1301
dc.identifier.issn 0024-3205
dc.identifier.uri http://hdl.handle.net/10016/9344
dc.description.abstract Monitoring gene therapy of glycogen storage disease type 1a in a mouse model was achieved using [18F]FDG and a dedicated animal scanner. The G6Pase knockout (KO) mice were compared to the same mice after infusion with a recombinant adenovirus containing the murine G6Pase gene (Ad-mG6Pase). Serial images of the same mouse before and after therapy were obtained and compared with wild-type (WT) mice of the same strain to determine the uptake and retention of [18F]FDG in the liver. Image data were acquired from heart, blood pool and liver for twenty minutes after injection of [18F]FDG. The retention of [18F]FDG was lower for the WT mice compared to the KO mice. The mice treated with adenovirus-mediated gene therapy had retention similar to that found in age-matched WT mice. These studies show that FDG can be used to monitor the G6Pase concentration in liver of WT mice as compared to G6Pase KO mice. In these mice, gene therapy returned the liver function to that found in age matched WT controls as measured by the FDG kinetics in the liver compared to that found in age matched wild type controls
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier
dc.subject.other Glycogen storage disease type 1a
dc.subject.other Mouse
dc.subject.other [18F]FDG
dc.subject.other G6Pase
dc.title Monitoring the correction of glycogen storage disease type 1a in a mouse model using [18F]FDG and a dedicated animal scanner
dc.type article
dc.type.review PeerReviewed
dc.description.status Publicado
dc.relation.publisherversion http://dx.doi.org/10.1016/S0024-3205(02)01831-3
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1016/S0024-3205(02)01831-3
dc.rights.accessRights openAccess
dc.identifier.publicationfirstpage 1293
dc.identifier.publicationissue 11
dc.identifier.publicationlastpage 1301
dc.identifier.publicationtitle Life Sciences
dc.identifier.publicationvolume 71
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