Publication: Improving PET Quantification of Small Animal [Ga-68]DOTA-Labeled PET/CT Studies by Using a CT-Based Positron Range Correction
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2018-08-01
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Springer
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Abstract
Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since generators accessibility has made Ga-68 tracers wide available, the aim of this study is to show how the quantitative results of [Ga-68]DOTA-labeled PET/X-ray computed tomography (CT) imaging of neuroendocrine tumors in mice can be improved using positron range correction (PRC).
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Emission tomography, Preclinical evaluation, Mathematical removal, Spatial resolution, Magnetic field, Shine through, Image quality, 3d pet, Reconstruction, System
Bibliographic citation
Cal-Gonzalez, J., Vaquero, J.J., Herraiz, J.L. et al. Improving PET Quantification of Small Animal [68Ga]DOTA-Labeled PET/CT Studies by Using a CT-Based Positron Range Correction. Mol Imaging Biol 20, 584–593 (2018)