RT Journal Article
T1 Improving PET Quantification of Small Animal [Ga-68]DOTA-Labeled PET/CT Studies by Using a CT-Based Positron Range Correction
A1 Cal González, Jacobo
A1 Vaquero López, Juan José
A1 Herraiz, Joaquín L.
A1 Pérez Liva, Mailyn
A1 Soto Montenegro, Mª Luisa
A1 Peña Zalbidea, Santiago
A1 Desco Menéndez, Manuel
A1 Udias Moinelo, José Manuel
AB Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since generators accessibility has made Ga-68 tracers wide available, the aim of this study is to show how the quantitative results of [Ga-68]DOTA-labeled PET/X-ray computed tomography (CT) imaging of neuroendocrine tumors in mice can be improved using positron range correction (PRC).
PB Springer
SN 1536-1632
SN 1860-2002 (electronic)
YR 2018
FD 2018-08-01
LK https://hdl.handle.net/10016/36022
UL https://hdl.handle.net/10016/36022
LA eng
NO This work was partially funded by the projects RTC-2015-3772-1, TEC2014-56600-R, and TEC2016-78052-R from the Spanish Ministry of Science and Innovation, Spanish Government, Spanish Ministry of Economy and Competitiveness grants (FIS PI11/00616, FIS PI14/00860, CP08/00017, and CPII14/00005) co-financed by European Regional Development Fund (ERDF), Alicia Koplowitz Foundation and TOPUS S2013/MIT-3024 project from the regional government of Madrid. The research leading to these results has received funding from the Innovative Medicines Initiative (www.imi.europa.eu) Joint Undertaking under grant agreement n°115337, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and EFPIA companies’ in kind contribution. Part of the calculations were performed in the “Clúster de Cálculo de Alta Capacidad para Técnicas Físicas” funded by UCM and by UE under the FEDER programme.
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