Association of porcine swine leukocyte antigen (Sla) haplotypes with b-and t-cell immune response to foot-and-mouth disease virus (fmdv) peptides

e-Archivo Repository

e-Archivo estará en modo consulta durante los próximos días. Por favor, NO DEPOSITE ningún trabajo. Los enlaces a través del handle no están accesibles, si necesita hacer una búsqueda de sus publicaciones, pinche en "Navegar por" "Autores". Disculpen las molestias.

Show simple item record León, Patricia de Cañas Arranz, Rodrigo Sáez Achaerandio, Yago Forner, Mar Defaus, Sira Cuadra Fernández, María Dolores Bustos, María J. Torres, Elisa Andreu, David Blanco, Esther Sobrino, Francisco Hammer, Sabine E. 2022-02-11T12:20:46Z 2022-02-11T12:20:46Z 2020-09-08
dc.identifier.bibliographicCitation de León, P.; Cañas-Arranz, R.; Saez, Y.; Forner, M.; Defaus, S.; Cuadra, D.; Bustos, M.J.; Torres, E.; Andreu, D.; Blanco, E.; Sobrino, F.; Hammer, S.E. Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides. Vaccines 2020, 8, 513.
dc.identifier.issn 2076-393X
dc.description.abstract Dendrimer peptides are promising vaccine candidates against the foot-and-mouth disease virus (FMDV). Several B-cell epitope (B2T) dendrimers, harboring a major FMDV antigenic B-cell site in VP1 protein, are covalently linked to heterotypic T-cell epitopes from 3A and/or 3D proteins, and elicited consistent levels of neutralizing antibodies and IFN-gamma-producing cells in pigs. To address the contribution of the highly polymorphic nature of the porcine MHC (SLA, swine leukocyte antigen) on the immunogenicity of B2T dendrimers, low-resolution (Lr) haplotyping was performed. We looked for possible correlations between particular Lr haplotypes with neutralizing antibody and T-cell responses induced by B2T peptides. In this study, 63 pigs immunized with B2T dendrimers and 10 non-immunized (control) animals are analyzed. The results reveal a robust significant correlation between SLA class-II Lr haplotypes and the T-cell response. Similar correlations of T-cell response with SLA class-I Lr haplotypes, and between B-cell antibody response and SLA class-I and SLA class-II Lr haplotypes, were only found when the sample was reduced to animals with Lr haplotypes represented more than once. These results support the contribution of SLA class-II restricted T-cells to the magnitude of the T-cell response and to the antibody response evoked by the B2T dendrimers, being of potential value for peptide vaccine design against FMDV.
dc.description.sponsorship This work was supported by the Spanish Ministry of Science, Innovation and Universities (grant AGL2017-89097-C2 to F.S. and D.A.; AGL2016-76445-R to E.B.; PGC2018-096849-B-I00 to Y.S. and D.C.), Comunidad de Madrid co-financed with ECFEDER funds (P2018/BAA-4370 to F.S. and E.B.) and Generalitat de Catalunya (2009SGR492 to D.A.). Work at Centro de Biología Molecular “Severo Ochoa” and at UPF was supported by Fundación Ramón Areces and by the Maria de Maeztu Program of the Spanish Ministry of Science, Innovation and Universities, respectively. R. Cañas-Arranz and M. Forner were holders of a PhD fellowship from the Spanish Ministry of Science, Innovation and University (FPI programme).
dc.language.iso eng
dc.publisher MDPI
dc.rights © 2020 by the authors
dc.rights Atribución 3.0 España
dc.subject.other adaptive immunity
dc.subject.other dendrimer peptide
dc.subject.other foot-and-mouth diseae virus
dc.subject.other protection
dc.subject.other sla polymorphism
dc.subject.other swine
dc.subject.other swine leukocyte antigen
dc.subject.other vaccine
dc.title Association of porcine swine leukocyte antigen (Sla) haplotypes with b-and t-cell immune response to foot-and-mouth disease virus (fmdv) peptides
dc.type research article
dc.subject.eciencia Informática
dc.rights.accessRights open access
dc.relation.projectID Gobierno de España. PGC2018-096849-B-I00
dc.relation.projectID Comunidad de Madrid. P2018/BAA-4370
dc.identifier.publicationfirstpage 1
dc.identifier.publicationissue 3
dc.identifier.publicationlastpage 16
dc.identifier.publicationtitle Vaccines
dc.identifier.publicationvolume 8
dc.identifier.uxxi AR/0000027477
dc.contributor.funder Comunidad de Madrid
dc.contributor.funder European Commission
dc.affiliation.dpto UC3M. Departamento de Informática
dc.affiliation.grupoinv UC3M. Grupo de Investigación: Computación Evolutiva y Redes Neuronales (EVANNAI)
dc.type.hasVersion VoR
 Find Full text

Files in this item

*Click on file's image for preview. (Embargoed files's preview is not supported)

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record