Publication: Chemical surface modification of bio-functionalized thin films using cross-linking agents
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Publication date
2019-06
Defense date
2019-07-05
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Abstract
The
biomaterials
group
at
CTB
has
developed
a
new
technique
for
the
biofunctionalization of a wide range of materials with primary amines. Numerous
proteins and other biomolecules were covalently bound to the amine groups using the
EDC/NHS chemistry as cross-linking agents. The aim of this work is to study material
bio functionalization with other crosslinking agents; Sulfhydryl group will be studied as
a reversible way of crosslinking proteins to a surface through disulfide bond formation.
We hypothesize that this molecules will yield better material-cell interactions and
improve the bioactivity of biocompatible materials such as silicon, titanium and glass.
Complementarily the protein adsorption process onto a solid surface will be investigated
to characterize it in both static and dynamic conditions.
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Keywords
Protein adsorption, Biofunctionalization, Crosslinking agents, Biocompatibility