Publication: Whole organ bioengineering: design and automation of a recellularization bioreactor
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2017-09
Defense date
2017-10-06
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Abstract
Organ transplantation has saved millions of lives because it is currently the only
permanent solution for several diseases. Nevertheless, there are huge drawbacks to
overcome such as organ shortage, immune rejection and the need of whole-life
immunosupressive regimens. There have been different attempts to solve this problem
as 3D organ printing, hepatocyte transplantation, artificial and bioartificial organs.
However, it has been shown that Tissue Engineering and Regenerative Medicine are the
real solution and have become the future of organ transplantation.
In order to obtain functional bioengineered organs, bioreactors need to be used
to automatize and optimize decellularization and recellularization processes. This
Bachelor Thesis is intended to design, program and build some of the components of a
liver recellularization bioreactor. Specifically, five syringe pumps, two peristaltic
pumps, a pH-meter, a level and a weight sensor will be developed. Moreover, this thesis
belongs to a bigger project whose main objective is the generation of functional livers
that could be transplanted into human patients.
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Keywords
Tissue engineering, Regenerative medicine, Bioengineering, Bioreactor, Recellularization, Extracellular matrix and guided user interface