Normothermic perfusion ofan isolated liver: control software implementation

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dc.contributor.advisor Jorcano Noval, José Luis
dc.contributor.advisor Cañizo López, Juan Francisco del Gullón Vega, Lucia 2018-03-09T18:11:00Z 2018-03-09T18:11:00Z 2014-09 2014-10-01
dc.description.abstract The current concern about the shortage of available liver donors for transplantation poses different possibilities that help overcoming this problem. New techniques for organ preservation, organ recovery methods of those organs classified as non viable in the first place, or the still under development method of decellularization followed by the recellularization of organs, stand as the most promising solutions nowadays. Along with the primary objective, these approaches also have in common a perfusion step of the organ. This study proposes a newly developed normothermic perfusion machine with a PC control. It provides a user-friendly platform for liver perfusion with the implementation of a software control that accomplishes an autonomous and homogeneous system able to adapt and adjust to the characteristics of the organ. The circuit is constituted by a whole set of devices that are electronically interconnected in order to work one depending on each other, resembling the physiology that interacts with the liver in a real body. These allow an instant measurement of meaningful values and blood parameters of the current state of the system. Results show a stable and constant-parameter control able to work independently of human surveillance during 24 hours while maintaining organ function and viability. It becomes an easier and more accurate system that will improve and make more reliable perfusion experiments in these lines of research that work against the actual lack of liver donors. It offers not only an improved method over the actual ones, but also presents a design able to implement future clinical evaluations into the software environment.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España
dc.subject.other Liver transplantation
dc.subject.other Normothermic perfusion machine
dc.subject.other PID algorithm
dc.subject.other Biotecnología
dc.title Normothermic perfusion ofan isolated liver: control software implementation
dc.type bachelorThesis
dc.subject.eciencia Biología y Biomedicina
dc.rights.accessRights openAccess Ingeniería Biomédica
dc.contributor.departamento Universidad Carlos III de Madrid. Departamento de Bioingeniería e Ingeniería Aeroespacial
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