Publication: Normothermic perfusion ofan isolated liver: control software implementation
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2014-09
Defense date
2014-10-01
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Abstract
The current concern about the shortage of available liver donors for transplantation poses
different possibilities that help overcoming this problem. New techniques for organ preservation,
organ recovery methods of those organs classified as non viable in the first place, or the still under
development method of decellularization followed by the recellularization of organs, stand as the
most promising solutions nowadays. Along with the primary objective, these approaches also have
in common a perfusion step of the organ. This study proposes a newly developed normothermic
perfusion machine with a PC control. It provides a user-friendly platform for liver perfusion with
the implementation of a software control that accomplishes an autonomous and homogeneous
system able to adapt and adjust to the characteristics of the organ. The circuit is constituted by a
whole set of devices that are electronically interconnected in order to work one depending on each
other, resembling the physiology that interacts with the liver in a real body. These allow an instant
measurement of meaningful values and blood parameters of the current state of the system. Results
show a stable and constant-parameter control able to work independently of human surveillance
during 24 hours while maintaining organ function and viability. It becomes an easier and more
accurate system that will improve and make more reliable perfusion experiments in these lines of
research that work against the actual lack of liver donors. It offers not only an improved method
over the actual ones, but also presents a design able to implement future clinical evaluations into the
software environment.
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Keywords
Liver transplantation, Normothermic perfusion machine, PID algorithm, Biotecnología