Perfusion bioreactor for liver bioengineering

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End-stage organ failure has grown to become one of the key challenges for the medical community because of the high number of patients in waiting list for a transplant and the severe shortage of suitable organ donors. These, together with population ageing, have created an accumulation phenomenon of patients which increases the severity of the problem. New techniques for organ preservation, organ recovery from organs not suitable for transplant, and organ recellularization attempt to tackle this problem, appearing as some of the most promising solutions. The aim of this bachelor thesis is to continue the development of a complex liver perfusion bioreactor in order to design and develop an efficient and repeatable method for organ perfusion, decellularization and recellularization, with the final objective being the creation of a perfusion bioreactor for liver bioengineering able to be used for organ perfusion and preservation, organ decellularization and organ recellularization, able to preserve cell structure, functionality, growth and control differentiation for up to 4 weeks, while avoiding contamination and automating as much as possible the process. In order to do this, the bioreactor will include many sensors and data acquisition systems as well as control systems for pressure, flow rate, and temperature among others.
Liver perfusion bioreactor, Organ perfusion and preservation, Preservation of cell structure
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