Publication: Effect of influenza-induced fever on human bioimpedance values
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2015-04-27
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Public Library of Science
Abstract
Background and Aims
Bioelectrical impedance analysis (BIA) is a widely used technique to assess body composition
and nutritional status. While bioelectrical values are affected by diverse variables, there
has been little research on validation of BIA in acute illness, especially to understand prognostic
significance. Here we report the use of BIA in acute febrile states induced
by influenza.
Methods
Bioimpedance studies were conducted during an H1N1 influenza A outbreak in Venezuelan
Amerindian villages from the Amazonas. Measurements were performed on 52 subjects between
1 and 40 years of age, and 7 children were re-examined after starting Oseltamivir
treatment. Bioelectrical Impedance Vector Analysis (BIVA) and permutation tests
were applied.
Results
For the entire sample, febrile individuals showed a tendency toward greater reactance
(p=0.058) and phase angle (p=0.037) than afebrile individuals, while resistance and impedance
were similar in the two groups. Individuals with repeated measurements showed significant
differences in bioimpedance values associated with fever, including increased
reactance (p<0.001) and phase angle (p=0.007), and decreased resistance (p=0.007) and
impedance (p<0.001).
Conclusions
There are bioelectrical variations induced by influenza that can be related to dehydration,
with lower extracellular to intracellular water ratio in febrile individuals, or a direct thermal effect.
Caution is recommended when interpreting bioimpedance results in febrile states.
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Bibliographic citation
Marini, E., Buffa, R., Contreras, M., Magris, M., Hidalgo, G., Sanchez, W., Ortiz, V., Urbaez, M., Cabras, S., Blaser, M. J., & Dominguez-Bello, M. G. (2015). Effect of Influenza-Induced Fever on Human Bioimpedance Values. PLOS ONE, 10 (4), p. e0125301.