Publication: Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity
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2021-03-10
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Springer Science and Business Media LLC
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Abstract
Deep brain stimulation (DBS) is a powerful neurostimulation therapy proposed for the treatment
of several neuropsychiatric disorders. However, DBS mechanism of action remains unclear, being
its effects on brain dynamics of particular interest. Specifically, DBS reversibility is a major point
of debate. Preclinical studies in obesity showed that the stimulation of the lateral hypothalamus
(LH) and nucleus accumbens (NAcc), brain centers involved in satiety and reward circuits, are able
to modulate the activity of brain structures impaired in this pathology. Nevertheless, the long-term
persistence of this modulation after DBS withdrawal was unexplored. Here we examine the in vivo
presence of such changes 1 month after LH- and NAcc-DBS, along with differences in synaptic
plasticity, following an exploratory approach. Thus, both stimulated and non-stimulated animals
with electrodes in the NAcc showed a common pattern of brain metabolism modulation, presumably
derived from the electrodes’ presence. In contrast, animals stimulated in the LH showed a relative
metabolic invariance, and a reduction of neuroplasticity molecules, evidencing long-lasting neural
changes. Our findings suggest that the reversibility or persistence of DBS modulation in the long-term
depends on the selected DBS target. Therefore, the DBS footprint would be influenced by the stability
achieved in the neural network involved during the stimulation.
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Casquero-Veiga, M., Bueno-Fernandez, C., Romero-Miguel, D., Lamanna-Rama, N., Nacher, J., Desco, M., & Soto-Montenegro, M. L. (2021). Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity. In Scientific Reports (Vol. 11, Issue 1). Springer Science and Business Media LLC.