RT Journal Article
T1 Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity
A1 Casquero-Veiga, Marta
A1 Bueno Fernández, Clara
A1 Romero Miguel, Luis Diego
A1 Lamanna Rama, Nicolás
A1 Nacher, Juan
A1 Desco Menéndez, Manuel
A1 Soto Montenegro, Mª Luisa
AB Deep brain stimulation (DBS) is a powerful neurostimulation therapy proposed for the treatmentof several neuropsychiatric disorders. However, DBS mechanism of action remains unclear, beingits effects on brain dynamics of particular interest. Specifically, DBS reversibility is a major pointof debate. Preclinical studies in obesity showed that the stimulation of the lateral hypothalamus(LH) and nucleus accumbens (NAcc), brain centers involved in satiety and reward circuits, are ableto modulate the activity of brain structures impaired in this pathology. Nevertheless, the long-termpersistence of this modulation after DBS withdrawal was unexplored. Here we examine the in vivopresence of such changes 1 month after LH- and NAcc-DBS, along with differences in synapticplasticity, following an exploratory approach. Thus, both stimulated and non-stimulated animalswith electrodes in the NAcc showed a common pattern of brain metabolism modulation, presumablyderived from the electrodes’ presence. In contrast, animals stimulated in the LH showed a relativemetabolic invariance, and a reduction of neuroplasticity molecules, evidencing long-lasting neuralchanges. Our findings suggest that the reversibility or persistence of DBS modulation in the long-termdepends on the selected DBS target. Therefore, the DBS footprint would be influenced by the stabilityachieved in the neural network involved during the stimulation.
PB Springer Science and Business Media LLC
SN 2045-2322
YR 2021
FD 2021-03-10
LK https://hdl.handle.net/10016/34716
UL https://hdl.handle.net/10016/34716
LA eng
NO This research was supported by the Ministerio de Ciencia,Innovación y Universidades, Instituto de Salud Carlos III (projects PI14/00860 and PI17/01766, and grantCPII14/00005), co-financed by European Regional Development Fund (ERDF), “A way of making Europe”,CIBERSAM, Delegación del Gobierno para el Plan Nacional sobre Drogas (2017/085), Fundación Mapfre andFundación Alicia Koplowitz. MCV was supported by Fundación Tatiana Pérez de Guzmán el Bueno as scholarshipholder of this institution. DRM was supported by Consejería de Educación e Investigación, Comunidadde Madrid, co-funded by European Social Fund “Investing in your future” (grant, PEJD-2018-PRE/BMD-7899). NLR was supported by Instituto de Investigación Sanitaria Gregorio Marañón, "Programa Intramural deImpulso a la I+D+I 2019”. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministeriode Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence(SEV‐2015‐0505). Support for Nacher’s lab came from Ministry of Economy and Competitiveness (SAF2015-68436-R), Generalitat Valenciana (PROMETEO2013/069) and Fundación Alicia Koplowitz (FAK2012/01).
DS e-Archivo
RD 1 sept. 2024