Publication: Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion
Loading...
Identifiers
Publication date
2015-09-13
Defense date
Advisors
Tutors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Impact
Export
Abstract
The synthesis of 3-, 5- and 8-arm dimethylaminoethyl methacrylate star polymers are reported, final Mn (PDI) = 12.2 K (1.09), 18.9K (1.10) and 38.4 K (1.11), respectively. The synthesis of 3-arm methyl methacrylate and dimethylaminoethyl methacrylate block co-polymer stars is also described. Living polymerisation occurred in all cases providing well defined stars with predictable molecular weights and narrow polydispersity. A fluorescent tag, 2-(8-methacryloyloy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoquinoline-1,3-dione, derived from a commercially available pigment, was incorporated into the star polymers. The fluorescence spectra of the polymers prepared were recorded over a range of pH and the peak emission frequency and intensity have been reported, λex = 462 nm. All of the multi-arm polymers exhibit fluorescence across a broad pH range with maximum emission at pH 4. A 3-arm star polymer has been demonstrated to show good bioadhesion in rat tissue. A reduced adhesion in epithelial tissues not covered by a viscoelastic mucus gel indicates an increased tendency for mucoadhesion over bioadhesion.
Description
Keywords
ATRP, Living radical polymerisation, Mucoadhesion, Bioadhesion, Star polymers, Fluorescent polymer
Bibliographic citation
Reactive and Functional Polymers, 2006, 66 (1), pp. 51-64.