RT Journal Article
T1 Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion
A1 Limer, Adam J.
A1 Rullay, Atvinder K.
A1 San Miguel Arnanz, Verónica
A1 Peinado, Carmen
A1 Keely, Simon
A1 Fitzpatrick, Eamonn
A1 Carrington, Stephen D.
A1 Brayden, David
A1 Haddleton, David
AB The synthesis of 3-, 5- and 8-arm dimethylaminoethyl methacrylate star polymers are reported, final Mn (PDI) = 12.2 K (1.09), 18.9K (1.10) and 38.4 K (1.11), respectively. The synthesis of 3-arm methyl methacrylate and dimethylaminoethyl methacrylate block co-polymer stars is also described. Living polymerisation occurred in all cases providing well defined stars with predictable molecular weights and narrow polydispersity. A fluorescent tag, 2-(8-methacryloyloy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoquinoline-1,3-dione, derived from a commercially available pigment, was incorporated into the star polymers. The fluorescence spectra of the polymers prepared were recorded over a range of pH and the peak emission frequency and intensity have been reported, λex = 462 nm. All of the multi-arm polymers exhibit fluorescence across a broad pH range with maximum emission at pH 4. A 3-arm star polymer has been demonstrated to show good bioadhesion in rat tissue. A reduced adhesion in epithelial tissues not covered by a viscoelastic mucus gel indicates an increased tendency for mucoadhesion over bioadhesion.
PB Elsevier
SN 1381-5148
YR 2015
FD 2015-09-13
LK https://hdl.handle.net/10016/24523
UL https://hdl.handle.net/10016/24523
LA eng
NO We thank Clariant for the kind donation of the hostasol precursor and Genzyme for part funding this work. D.M. Haddleton would also like to thank Professor John Ebdon for all of his encouragement and support throughout his academic career.
DS e-Archivo
RD 20 may. 2024