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Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion

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dc.affiliation.dptoUC3M. Departamento de Ciencia e Ingeniería de Materiales e Ingeniería Químicaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Polímeros y Compositeses
dc.contributor.authorLimer, Adam J.
dc.contributor.authorRullay, Atvinder K.
dc.contributor.authorSan Miguel Arnanz, Verónica
dc.contributor.authorPeinado, Carmen
dc.contributor.authorKeely, Simon
dc.contributor.authorFitzpatrick, Eamonn
dc.contributor.authorCarrington, Stephen D.
dc.contributor.authorBrayden, David
dc.contributor.authorHaddleton, David
dc.date.accessioned2017-05-03T09:10:08Z
dc.date.available2017-05-03T09:10:08Z
dc.date.issued2015-09-13
dc.description.abstractThe synthesis of 3-, 5- and 8-arm dimethylaminoethyl methacrylate star polymers are reported, final Mn (PDI) = 12.2 K (1.09), 18.9K (1.10) and 38.4 K (1.11), respectively. The synthesis of 3-arm methyl methacrylate and dimethylaminoethyl methacrylate block co-polymer stars is also described. Living polymerisation occurred in all cases providing well defined stars with predictable molecular weights and narrow polydispersity. A fluorescent tag, 2-(8-methacryloyloy-3,6-dioxaoctyl)thioxantheno[2,1,9-dej]isoquinoline-1,3-dione, derived from a commercially available pigment, was incorporated into the star polymers. The fluorescence spectra of the polymers prepared were recorded over a range of pH and the peak emission frequency and intensity have been reported, λex = 462 nm. All of the multi-arm polymers exhibit fluorescence across a broad pH range with maximum emission at pH 4. A 3-arm star polymer has been demonstrated to show good bioadhesion in rat tissue. A reduced adhesion in epithelial tissues not covered by a viscoelastic mucus gel indicates an increased tendency for mucoadhesion over bioadhesion.en
dc.description.sponsorshipWe thank Clariant for the kind donation of the hostasol precursor and Genzyme for part funding this work. D.M. Haddleton would also like to thank Professor John Ebdon for all of his encouragement and support throughout his academic career.en
dc.format.extent14
dc.format.mimetypeapplication/pdf
dc.identifier.bibliographicCitationReactive and Functional Polymers, 2006, 66 (1), pp. 51-64.en
dc.identifier.doihttps://dx.doi.org/10.1016/j.reactfunctpolym.2005.07.024
dc.identifier.issn1381-5148
dc.identifier.publicationfirstpage51
dc.identifier.publicationissue1
dc.identifier.publicationlastpage64
dc.identifier.publicationtitleReactive and Functional Polymersen
dc.identifier.publicationvolume66
dc.identifier.urihttps://hdl.handle.net/10016/24523
dc.identifier.uxxiAR/0000019780
dc.language.isoengen
dc.publisherElsevieren
dc.rights© Elsevier, 2005
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.ecienciaMaterialeses
dc.subject.ecienciaQuímicaes
dc.subject.otherATRPen
dc.subject.otherLiving radical polymerisationen
dc.subject.otherMucoadhesionen
dc.subject.otherBioadhesionen
dc.subject.otherStar polymersen
dc.subject.otherFluorescent polymeren
dc.titleFluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesionen
dc.typeresearch article*
dc.type.hasVersionAM*
dspace.entity.typePublication
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