Molecular imaging of pulmonary tuberculosis in an ex-vivo mouse model using spectral photon-counting computed tomography and micro-CT

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dc.contributor.author Lowe, Chiara
dc.contributor.author Ortega Gil, Ana
dc.contributor.author Muñoz Barrutia, María Arrate
dc.contributor.author Vaquero López, Juan José
dc.date.accessioned 2021-05-12T14:32:41Z
dc.date.available 2021-05-12T14:32:41Z
dc.date.issued 2021-04-29
dc.identifier.bibliographicCitation IEEE Acces, vol. 9, April 2021, Pp. 67201-67208
dc.identifier.issn 2169-3536
dc.identifier.uri http://hdl.handle.net/10016/32612
dc.description Artículo escrito por un elevado número de autores. Sólo se referencian el que aparece en primer lugar y los autores pertenecientes a la UC3M
dc.description.abstract The results of this study support the idea that photon-counting CT imaging is capable of molecular imaging when enhanced by high-Z pharmaceuticals. The Medipix3RX detector operating four CSM energy bins provided sufficient spectral information for the simultaneous differentiation of iodine, water, and lipid (and a second high-Z contrast). In an ex-vivo mouse model of chronic TB, detection of iodine contrast enabled segmentation and volume quantification of healthy and disease-related lung tissue. The results demonstrated the potential clinical utility of photon-counting CT imaging for molecular imaging in infectious lung diseases. In the future, if a TB-specific drug were to be incorporated with a high-Z nanoparticle, spectral CT could provide non-invasive evaluation of drug delivery and response to treatment. Such an imaging platform would have the potential to assist diagnosis and accelerate the development of novel therapies, which is essential for the eradication of TB. Photon-counting CT technology offers improved spatial and energy resolution. Thus, it is a promising next step in the evolution of CT.
dc.description.sponsorship The authors would like to acknowledge the Medipix2, Medipix3, and Medipix4 collaborations. They would also like to take this opportunity to acknowledge the generous support of the MARS Collaboration. They would also like to acknowledge Dr. Guembe from CIMA-Universidad de Navarra for preparing and staining the tissue sections.
dc.format.extent 8
dc.language.iso eng
dc.publisher IEEE
dc.rights This work is licensed under a Creative Commons Attribution 4.0 License.
dc.rights Atribución 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es/
dc.subject.other Lung
dc.subject.other Computed tomography
dc.subject.other Imaging
dc.subject.other Photonics
dc.subject.other Iodine
dc.subject.other Molecular imaging
dc.subject.other Drugs
dc.title Molecular imaging of pulmonary tuberculosis in an ex-vivo mouse model using spectral photon-counting computed tomography and micro-CT
dc.type article
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi https://doi.org/10.1109/ACCESS.2021.3076432
dc.rights.accessRights openAccess
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 67201
dc.identifier.publicationlastpage 67208
dc.identifier.publicationtitle IEEE Access
dc.identifier.publicationvolume 9
dc.identifier.uxxi AR/0000027870
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