Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naive adults with attention deficit hyperactivity disorder

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dc.contributor.author Marcos Vidal, Luis
dc.contributor.author Martinez Garcia, Magdalena Teresa
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Vilarroya, Óscar
dc.contributor.author Carmona Cañabate, Susana
dc.date.accessioned 2021-02-05T12:46:27Z
dc.date.available 2021-02-05T12:46:27Z
dc.date.issued 2019-11
dc.identifier.bibliographicCitation Pretus, C., Marcos‐Vidal, L., Martínez‐García, M., Picado, M., Ramos‐Quiroga, J. A., Richarte, V., Castellanos, F. X., Sepulcre, J., Desco, M., Vilarroya, Ó., Carmona, S. (2019). Stepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder. Human Brain Mapping, 40(16), 4645–4656.
dc.identifier.issn 1065-9471
dc.identifier.uri http://hdl.handle.net/10016/31868
dc.description.abstract Neuroimaging studies indicate that children with attention-deficit/hyperactivity disorder (ADHD) present alterations in several functional networks of the sensationto-cognition spectrum. These alterations include functional overconnectivity within sensory regions and underconnectivity between sensory regions and neural hubs supporting higher order cognitive functions. Today, it is unknown whether this same pattern of alterations persists in adult patients with ADHD who had never been medicated for their condition. The aim of the present study was to assess whether medication-naïve adults with ADHD presented alterations in functional networks of the sensation-to-cognition spectrum. Thirty-one medication-naïve adults with ADHD and twenty-two healthy adults underwent resting-state functional magnetic resonance imaging (rs-fMRI). Stepwise functional connectivity (SFC) was used to characterize the pattern of functional connectivity between sensory seed regions and the rest of the brain at direct, short, intermediate, and long functional connectivity distances, thus covering the continuum from the sensory input to the neural hubs supporting higher order cognitive functions. As compared to controls, adults with ADHD presented increased SFC degree within primary sensory regions and decreased SFC degree between sensory seeds and higher order integration nodes. In addition, they exhibited decreased connectivity degree between sensory seeds and regions of the default-mode network. Consistently, the higher the score in clinical severity scales the lower connectivity degree between seed regions and the default mode network.
dc.description.sponsorship This work was supported by the Ministerio de Economía y Competitividad research grant (SAF2012-32362) and the Instituto de Salud Carlos III (Miguel Servet Type I (CP16/00096), AES Grant (PI17/00064), and P-FIS Grant (FI18/00255)).
dc.format.extent 12
dc.language.iso eng
dc.publisher Wiley
dc.rights © 2019 Wiley Periodicals, Inc
dc.subject.other ADHD
dc.subject.other Adult ADHD
dc.subject.other Default mode network
dc.subject.other Resting-State fMRI
dc.subject.other Stepwise functional connectivity
dc.title Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naive adults with attention deficit hyperactivity disorder
dc.type article
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi https://doi.org/10.1002/hbm.24727
dc.rights.accessRights openAccess
dc.relation.projectID Gobierno de España. SAF2012-32362
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 4645
dc.identifier.publicationissue 16
dc.identifier.publicationlastpage 4656
dc.identifier.publicationtitle Human Brain Mapping
dc.identifier.publicationvolume 40
dc.identifier.uxxi AR/0000024427
dc.contributor.funder Ministerio de Economía y Competitividad (España)
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