Biodegradable and thermoresponsive micelles of triblock copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and ε-caprolactone for controlled drug delivery

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dc.contributor.author San Miguel Arnanz, Verónica
dc.contributor.author Limer, Adam J.
dc.contributor.author Haddleton, David
dc.contributor.author Catalina, Fernando
dc.contributor.author Peinado, Carmen
dc.date.accessioned 2017-05-03T10:58:47Z
dc.date.available 2017-05-03T10:58:47Z
dc.date.issued 2008-08-18
dc.identifier.bibliographicCitation European Polymer Journal, 2008, 44 (11), pp. 3853-3863.
dc.identifier.issn 0014-3057
dc.identifier.uri http://hdl.handle.net/10016/24526
dc.description.abstract Amphiphilic triblock copolymers, poly(2-(N,N-dimethylamino)ethyl methacrylate)x-block-poly(caprolactone)-block-poly(2-(N,N-dimethylamino)ethyl methacrylate)x, PDMAEMACo, were synthesized. Polymerization and structural features of the polymers were analyzed by different physicochemical techniques (GPC, ¹H NMR and FTIR). Formation of hydrophobic domains as cores of the micelles was studied by ¹H NMR and further confirmed by fluorescence. Dynamic light scattering measurements showed a monodispersed size distribution only for the copolymer with the lowest degree of polymerization, while increasing the length of PDMAEMA blocks leads to a bimodal size distribution. The micelles showed reversible dispersion/aggregation in response to temperature cycles through an outer polymer shell lower critical solution temperature (LCST) for PDMAEMA at temperatures between 54 and 87 °C. The triblock copolymer micelles were loaded with the sparingly water-soluble anticancer drug, chlorambucil, by a dialysis procedure. The drug release profile monitored by fluorescence showed that the release of chlorambucil from PDMAEMA nanoparticles is controlled by a combined degradation–diffusion mechanism.
dc.description.sponsorship The authors thank the Plan Nacional I + D + I (Ministerio de Educación y Ciencia) for financial support (MAT2006-05979) as well as the Comunidad Autónoma de Madrid for the funding through I + D Program (S0505/MAT-0227).
dc.format.extent 11
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © 2008 Elsevier
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.other Block copolymer
dc.subject.other Micelles
dc.subject.other Temperature sensitivity
dc.subject.other Controllable drug release
dc.subject.other Chemotherapy
dc.title Biodegradable and thermoresponsive micelles of triblock copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and ε-caprolactone for controlled drug delivery
dc.type article
dc.subject.eciencia Materiales
dc.subject.eciencia Química
dc.identifier.doi https://dx.doi.org/10.1016/j.eurpolymj.2008.07.056
dc.rights.accessRights openAccess
dc.relation.projectID Gobierno de España. MAT2006-05979
dc.relation.projectID Comunidad de Madrid. S0505/MAT-0227
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage 3853
dc.identifier.publicationissue 11
dc.identifier.publicationlastpage 3863
dc.identifier.publicationtitle European Polymer Journal
dc.identifier.publicationvolume 44
dc.identifier.uxxi AR/0000019785
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