Advances in optical imaging for pharmacological studies

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dc.contributor.author Arranz, Alicia
dc.contributor.author Ripoll Lorenzo, Jorge
dc.date.accessioned 2015-09-16T13:48:10Z
dc.date.available 2015-09-16T13:48:10Z
dc.date.issued 2015-09-11
dc.identifier.bibliographicCitation Frontiers in pharmacology, vol. 6, article 189 (Sept. 2015), pp. 1-7.
dc.identifier.issn 1663-9812
dc.identifier.uri http://hdl.handle.net/10016/21575
dc.description.abstract Imaging approaches are an essential tool for following up over time representative parameters of in vivo models, providing useful information in pharmacological studies. Main advantages of optical imaging approaches compared to other imaging methods are their safety, straight-forward use and cost-effectiveness. A main drawback, however, is having to deal with the presence of high scattering and high absorption in living tissues. Depending on how these issues are addressed, three different modalities can be differentiated: planar imaging (including fluorescence and bioluminescence in vivo imaging), optical tomography, and optoacoustic approaches. In this review we describe the latest advances in optical in vivo imaging with pharmacological applications, with special focus on the development of new optical imaging probes in order to overcome the strong absorption introduced by different tissue components, especially hemoglobin, and the development of multimodal imaging systems in order to overcome the resolution limitations imposed by scattering.
dc.description.sponsorship JR acknowledges support from the EC FP7 CIG grant HIGH-THROUGHPUT TOMO, and MINECO grant FIS 2013-41802-R MESO-IMAGING
dc.format.extent 7
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher EPFL (École polytechnique fédéral de Lausanne)
dc.rights © 2015 Arranz and Ripoll
dc.rights Atribución-CompartirIgual 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by-sa/3.0/es/
dc.subject.other Bioluminescence
dc.subject.other Planar fluorescence imaging
dc.subject.other Fluorescence molecular tomography
dc.subject.other Optoacoustics
dc.subject.other Multispectral optoacoustic tomography
dc.subject.other Multispectral imaging
dc.subject.other Hybrid systems
dc.subject.other Data processing
dc.title Advances in optical imaging for pharmacological studies
dc.type article
dc.relation.publisherversion http://dx.doi.org/10.3389/fphar.2015.00189
dc.subject.eciencia Biología y Biomedicina
dc.subject.eciencia Farmacia
dc.subject.eciencia Medicina
dc.subject.eciencia Óptica
dc.identifier.doi 10.3389/fphar.2015.00189
dc.rights.accessRights openAccess
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/333632
dc.relation.projectID Gobierno de España. FIS2013-41802-R/MESO-IMAGING
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 1
dc.identifier.publicationissue Article 189
dc.identifier.publicationlastpage 7
dc.identifier.publicationtitle Frontiers in pharmacology
dc.identifier.publicationvolume 6
dc.identifier.uxxi AR/0000017235
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