A method for small-animal PET/CT alignment calibration

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dc.contributor.author Pascau González-Garzón, Javier
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Chamorro Servent, Judit
dc.contributor.author Rodríguez Ruano, Alexia
dc.contributor.author Desco Menéndez, Manuel
dc.date.accessioned 2012-06-05T12:18:21Z
dc.date.available 2013-06-20T22:00:14Z
dc.date.issued 2012-06-21
dc.identifier.bibliographicCitation Physics in Medicine and Biology, (June 2012), 57(12), N199-N207
dc.identifier.issn 0031-9155 (Online)
dc.identifier.issn 1361-6560 (Online)
dc.identifier.uri http://hdl.handle.net/10016/14475
dc.description.abstract Small-animal positron-emission tomography/computed tomography (PET/ CT) scanners provide anatomical and molecular imaging, which enables the joint visualization and analysis of both types of data. A proper alignment calibration procedure is essential for small-animal imaging since resolution is much higher than that in human devices. This work presents an alignment phantom and two different calibration methods that provide a reliable and repeatable measurement of the spatial geometrical alignment between the PET and the CT subsystems of a hybrid scanner. The phantom can be built using laboratory materials, and it is meant to estimate the rigid spatial transformation that aligns both modalities. It consists of three glass capillaries filled with a positron-emitter solution and positioned in a non-coplanar triangular geometry inside the system field of view. The calibration methods proposed are both based on automatic line detection, but with different approaches to calculate the transformation of the lines between both modalities. Our results show an average accuracy of the alignment estimation of 0.39 mm over the whole field of view.
dc.description.sponsorship This study was funded by CDTI under the CENIT Program (AMIT Project), projects ARTEMIS S2009/DPI-1802 (CAM) and TEC2010-21619-C04-01, and supported by the Spanish Ministry of Economy and Competitiveness.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Institute of Physics
dc.rights © 2012 Institute of Physics and Engineering in Medicine
dc.subject.other Positron emission tomography
dc.subject.other Small-animal imaging
dc.subject.other PET
dc.title A method for small-animal PET/CT alignment calibration
dc.type article
dc.description.status Publicado
dc.relation.publisherversion http://dx.doi.org/10.1088/0031-9155/57/12/N199
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1088/0031-9155/57/12/N199
dc.rights.accessRights openAccess
dc.relation.projectID Comunidad de Madrid. S2009/DPI-1802/ARTEMIS
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage N199
dc.identifier.publicationissue 12
dc.identifier.publicationlastpage N207
dc.identifier.publicationtitle Physics in Medicine and Biology
dc.identifier.publicationvolume 57
dc.identifier.uxxi AR/0000010122
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