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A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal

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dc.affiliation.dptoUC3M. Departamento de Ingeniería Térmica y de Fluidoses
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Mecánica de Fluidoses
dc.contributor.authorSincomb, S.
dc.contributor.authorCoenen, Wilfried
dc.contributor.authorGutiérrez-Montes, C.
dc.contributor.authorMartínez Bazan, Jesús Carlos
dc.contributor.authorHaughton, V.
dc.contributor.authorSánchez, A. L.
dc.contributor.funderComunidad de Madrides
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es
dc.date.accessioned2023-03-27T07:46:57Z
dc.date.available2023-03-27T07:46:57Z
dc.date.issued2022-05-25
dc.description.abstractThe monitoring of intracranial pressure (ICP) fluctuations, which is needed in the context of a number of neurological diseases, requires the insertion of pressure sensors, an invasive procedure with considerable risk factors. Intracranial pressure fluctuations drive the wave-like pulsatile motion of cerebrospinal fluid (CSF) along the compliant spinal canal. Systematically derived simplified models relating the ICP fluctuations with the resulting CSF flow rate can be useful in enabling indirect evaluations of the former from non-invasive magnetic resonance imaging (MRI) measurements of the latter. As a preliminary step in enabling these predictive efforts, a model is developed here for the pulsating viscous motion of CSF in the spinal canal, assumed to be a linearly elastic compliant tube of slowly varying section, with a Darcy pressure-loss term included to model the fluid resistance introduced by the trabeculae, which are thin collagen-reinforced columns that form a web-like structure stretching across the spinal canal. Use of Fourier-series expansions enables predictions of CSF flow rate for realistic anharmonic ICP fluctuations. The flow rate predicted using a representative ICP waveform together with a realistic canal anatomy is seen to compare favourably with in vivo phase-contrast MRI measurements at multiple sections along the spinal canal. The results indicate that the proposed model, involving a limited number of parameters, can serve as a basis for future quantitative analyses targeting predictions of ICP temporal fluctuations based on MRI measurements of spinal-canal anatomy and CSF flow rate.en
dc.description.sponsorshipThe work of S.C., V.H. and A.L.S. was supported by the National Institute of Neurological Disorders and Stroke through contract no. 1R01NS120343-01. The work of W.C. was supported by the Comunidad de Madrid through the contract CSFFLOW-CM-UC3M. C.M.B., C.G. and W.C. acknowledge the support of the Spanish MICINN through the coordinated project PID2020-115961RB. C.M.B. and C.G. also acknowledge the support provided by Junta de Andalucía and European Funds through grant P18-FR-4619.en
dc.format.extent13
dc.identifier.bibliographicCitationSincomb, S., Coenen, W., Gutiérrez-Montes, C., Martínez Bazán, C., Haughton, V., & Sánchez, A. (2022). A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal. Journal of Fluid Mechanics, 939.en
dc.identifier.doihttps://doi.org/10.1017/jfm.2022.215
dc.identifier.issn0022-1120
dc.identifier.publicationfirstpageA26-1
dc.identifier.publicationlastpageA26-13
dc.identifier.publicationtitleJournal of Fluid Mechanicsen
dc.identifier.publicationvolume939
dc.identifier.urihttps://hdl.handle.net/10016/36963
dc.identifier.uxxiAR/0000031275
dc.language.isoeng
dc.publisherCambridge University Pressen
dc.relation.projectIDComunidad de Madrid. CSFFLOW-CM-UC3Mes
dc.relation.projectIDGobierno de España. PID2020-115961RBes
dc.rights© The Author(s), 2022. Published by Cambridge University Press.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaFísicaes
dc.subject.ecienciaIngeniería Industriales
dc.subject.ecienciaIngeniería Mecánicaes
dc.subject.ecienciaPsicologíaes
dc.subject.otherBiological fluid dynamicsen
dc.titleA one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canalen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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