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Neutral evolution and the acceleration of the molecular clock

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dc.affiliation.dptoUC3M. Departamento de Matemáticases
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Interdisciplinar de Sistemas Complejos (GISC)es
dc.contributor.authorCuesta, José A.
dc.date.accessioned2020-03-23T19:31:20Z
dc.date.available2020-03-23T19:31:20Z
dc.date.issued2015-02-04es
dc.description.abstractLarge sets of genotypes give rise to the same phenotype because phenotypic expressionis highly redundant. Accordingly, a population can accept mutations without alteringits phenotype, as long as the genotype mutates into another one on the same set. Bylinking every pair of genotypes that are mutually accessible through mutation, geno-types organize themselves into neutral networks (NN). These networks are known to beheterogeneous and assortative, and these properties affect the evolutionary dynamics ofthe population. By studying the dynamics of populations on NN with arbitrary topol-ogy we analyze the effect of assortativity, of NN (phenotype) fitness, and of networksize. We find that the probability that the population leaves the network is smallerthe longer the time spent on it. This progressive "phenotypic entrapment" entails asystematic increase in the overdispersion of the process with time and an accelerationin the fixation rate of neutral mutations.en
dc.format.extent1
dc.identifier.bibliographicCitationVII National Conference BIFI 2015, Zaragoza, February 4-6, 2015: book of abstracts. P. 7.en
dc.identifier.publicationfirstpage7
dc.identifier.publicationlastpage7
dc.identifier.publicationtitleVII National Conference BIFI 2015, Zaragoza, February 4-6, 2015: book of abstracts.en
dc.identifier.urihttps://hdl.handle.net/10016/30015
dc.identifier.uxxiCC/0000024842
dc.language.isoengen
dc.relation.eventdateFebruary 4-6, 2015en
dc.relation.eventplaceZaragozaes
dc.relation.eventtitleNational Conference (BIFI 2015)en
dc.relation.publisherversionhttp://www.bifi.es/events/bifi2015/sites/default/files/book_of_abstracts.pdf
dc.rights.accessRightsopen accessen
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaMatemáticases
dc.subject.otherPhenotypic entrapmenten
dc.subject.otherGenotypesen
dc.subject.otherMolecular clocken
dc.titleNeutral evolution and the acceleration of the molecular clocken
dc.typeconference proceedings*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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