Publication: Struggle for space: viral extinction through competition for cells
dc.affiliation.dpto | UC3M. Departamento de Matemáticas | es |
dc.affiliation.grupoinv | UC3M. Grupo de Investigación: Interdisciplinar de Sistemas Complejos (GISC) | es |
dc.contributor.author | Cuesta, José A. | |
dc.contributor.author | Aguirre, Jacobo | |
dc.contributor.author | Capitán, José A. | |
dc.contributor.author | Manrubia, Susanna C. | |
dc.date.accessioned | 2014-06-09T11:21:00Z | |
dc.date.available | 2014-06-09T11:21:00Z | |
dc.date.issued | 2011-01-14 | |
dc.description.abstract | The design of protocols to suppress the propagation of viral infections is an enduring enterprise, especially hindered by limited knowledge of the mechanisms leading to viral extinction. Here we report on infection extinction due to intraspecific competition to infect susceptible hosts. Beneficial mutations increase the production of viral progeny, while the host cell may develop defenses against infection. For an unlimited number of host cells, a feedback runaway coevolution between host resistance and progeny production occurs. However, physical space limits the advantage that the virus obtains from increasing offspring numbers; thus, infection clearance may result from an increase in host defenses beyond a finite threshold. Our results might be relevant to devise improved control strategies in environments with mobility constraints or different geometrical properties. | en |
dc.description.sponsorship | The authors acknowledge the support of the Spanish MICINN under projects FIS2008-05273 and MOSAICO and of Comunidad de Madrid (Spain) under project MODELICO-CM. | en |
dc.format.extent | 4 | es |
dc.format.mimetype | application/pdf | |
dc.identifier.bibliographicCitation | Physical review letters, 106 (2), pp. 028104 | en |
dc.identifier.doi | 10.1103/PhysRevLett.106.028104 | |
dc.identifier.issn | 0031-9007 | |
dc.identifier.publicationfirstpage | 1 | es |
dc.identifier.publicationissue | 2 (028104) | es |
dc.identifier.publicationlastpage | 4 | es |
dc.identifier.publicationtitle | Physical review letters | en |
dc.identifier.publicationvolume | 106 | es |
dc.identifier.uri | https://hdl.handle.net/10016/18967 | |
dc.identifier.uxxi | AR/0000007931 | |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.projectID | Comunidad de Madrid. S2009/ESP-1691/MODELICO | |
dc.relation.projectID | Gobierno de España. FIS2008-05273 | |
dc.relation.projectID | Gobierno de España. FIS2006-01485/MOSAICO | |
dc.relation.publisherversion | http://dx.doi.org/10.1103/PhysRevLett.106.028104 | es |
dc.rights | © 2011 American Physical Society | en |
dc.rights.accessRights | open access | en |
dc.subject.eciencia | Matemáticas | es |
dc.subject.eciencia | Medicina | es |
dc.subject.other | Error catastrophe | en |
dc.subject.other | Virus populations | en |
dc.subject.other | Evolution | en |
dc.subject.other | Supperssion | en |
dc.subject.other | Percolation | en |
dc.subject.other | Infectivity | en |
dc.subject.other | Resistance | en |
dc.subject.other | Threshold | en |
dc.subject.other | Genetics | en |
dc.title | Struggle for space: viral extinction through competition for cells | en |
dc.type | research article | * |
dc.type.hasVersion | VoR | * |
dspace.entity.type | Publication |
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