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Struggle for space: viral extinction through competition for cells

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dc.affiliation.dptoUC3M. Departamento de Matemáticases
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Interdisciplinar de Sistemas Complejos (GISC)es
dc.contributor.authorCuesta, José A.
dc.contributor.authorAguirre, Jacobo
dc.contributor.authorCapitán, José A.
dc.contributor.authorManrubia, Susanna C.
dc.date.accessioned2014-06-09T11:21:00Z
dc.date.available2014-06-09T11:21:00Z
dc.date.issued2011-01-14
dc.description.abstractThe design of protocols to suppress the propagation of viral infections is an enduring enterprise, especially hindered by limited knowledge of the mechanisms leading to viral extinction. Here we report on infection extinction due to intraspecific competition to infect susceptible hosts. Beneficial mutations increase the production of viral progeny, while the host cell may develop defenses against infection. For an unlimited number of host cells, a feedback runaway coevolution between host resistance and progeny production occurs. However, physical space limits the advantage that the virus obtains from increasing offspring numbers; thus, infection clearance may result from an increase in host defenses beyond a finite threshold. Our results might be relevant to devise improved control strategies in environments with mobility constraints or different geometrical properties.en
dc.description.sponsorshipThe authors acknowledge the support of the Spanish MICINN under projects FIS2008-05273 and MOSAICO and of Comunidad de Madrid (Spain) under project MODELICO-CM.en
dc.format.extent4es
dc.format.mimetypeapplication/pdf
dc.identifier.bibliographicCitationPhysical review letters, 106 (2), pp. 028104en
dc.identifier.doi10.1103/PhysRevLett.106.028104
dc.identifier.issn0031-9007
dc.identifier.publicationfirstpage1es
dc.identifier.publicationissue2 (028104)es
dc.identifier.publicationlastpage4es
dc.identifier.publicationtitlePhysical review lettersen
dc.identifier.publicationvolume106es
dc.identifier.urihttps://hdl.handle.net/10016/18967
dc.identifier.uxxiAR/0000007931
dc.language.isoenges
dc.publisherElsevieres
dc.relation.projectIDComunidad de Madrid. S2009/ESP-1691/MODELICO
dc.relation.projectIDGobierno de España. FIS2008-05273
dc.relation.projectIDGobierno de España. FIS2006-01485/MOSAICO
dc.relation.publisherversionhttp://dx.doi.org/10.1103/PhysRevLett.106.028104es
dc.rights© 2011 American Physical Societyen
dc.rights.accessRightsopen accessen
dc.subject.ecienciaMatemáticases
dc.subject.ecienciaMedicinaes
dc.subject.otherError catastropheen
dc.subject.otherVirus populationsen
dc.subject.otherEvolutionen
dc.subject.otherSupperssionen
dc.subject.otherPercolationen
dc.subject.otherInfectivityen
dc.subject.otherResistanceen
dc.subject.otherThresholden
dc.subject.otherGeneticsen
dc.titleStruggle for space: viral extinction through competition for cellsen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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