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Response to deep brain stimulation in three brain targets with implications in mental disorders: a PET study in rats

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédicaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Groupes
dc.contributor.authorCasquero-Veiga, Marta
dc.contributor.authorHadar, Ravit
dc.contributor.authorPascau González-Garzón, Javier
dc.contributor.authorWinter, Christine
dc.contributor.authorDesco Menéndez, Manuel
dc.contributor.authorSoto Montenegro, Mª Luisa
dc.contributor.funderComunidad de Madrides
dc.date.accessioned2023-11-08T13:20:06Z
dc.date.available2023-11-08T13:20:06Z
dc.date.issued2016-12-29
dc.description.abstractObjective: To investigate metabolic changes in brain networks by deep brain stimulation (DBS) of the medial prefrontal cortex (mPFC), nucleus accumbens (NAcc) and dorsomedial thalamus (DM) using positron emission tomography (PET) in naïve rats. Methods: 43 male Wistar rats underwent stereotactic surgery and concentric bipolar platinum-iridium electrodes were bilaterally implanted into one of the three brain sites. [18F]-fluoro-2-deoxy-glucose-PET (18FDG-PET) and computed tomography (CT) scans were performed at the 7th (without DBS) and 9th day (with DBS) after surgery. Stimulation period matched tracer uptake period. Images were acquired with a small-animal PET-CT scanner. Differences in glucose uptake between groups were assessed with Statistical Parametric Mapping. Results: DBS induced site-specific metabolic changes, although a common increased metabolic activity in the piriform cortex was found for the three brain targets. mPFC-DBS increased metabolic activity in the striatum, temporal and amygdala, and reduced it in the cerebellum, brainstem (BS) and periaqueductal gray matter (PAG). NAcc-DBS increased metabolic activity in the subiculum and olfactory bulb, and decreased it in the BS, PAG, septum and hypothalamus. DM-DBS increased metabolic activity in the striatum, NAcc and thalamus and decreased it in the temporal and cingulate cortex. Conclusions: DBS induced significant changes in 18FDG uptake in brain regions associated with the basal ganglia-thalamo-cortical circuitry. Stimulation of mPFC, NAcc and DM induced different patterns of 18FDG uptake despite interacting with the same circuitries. This may have important implications to DBS research suggesting individualized target selection according to specific neural modulatory requirements.en
dc.description.sponsorshipThis research was conducted under the EraNet Neuron framework (DBS_F20rat) and supported by the Federal Ministry of Education and Research, Germany (BMBF 01EW1103), the Ministry of Economy and Competitiveness ISCIII-FIS grants (PI14/00860, CPII/00005) co-financed by ERDF (FEDER) Funds from the European Commission, "A way of making Europe", Fundación Mapfre and Comunidad de Madrid (BRADE S2013/ICE-2958).en
dc.format.extent13
dc.identifier.bibliographicCitationCasquero-Veiga, M., Hadar, R., Pascau, J., Winter, C., Desco, M., & Soto-Montenegro, M. L. (2016). Response to deep brain stimulation in three brain targets with implications in mental disorders: a PET study in rats. PLOS ONE, 11(12), e0168689.en
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0168689
dc.identifier.issn1932-6203
dc.identifier.publicationfirstpage1
dc.identifier.publicationissue12, e0168689
dc.identifier.publicationlastpage13
dc.identifier.publicationtitlePLoS Oneen
dc.identifier.publicationvolume11
dc.identifier.urihttps://hdl.handle.net/10016/38796
dc.identifier.uxxiAR/0000018687
dc.language.isoengen
dc.publisherPLOSen
dc.relation.projectIDComunidad de Madrid. S2013/ICE-2958es
dc.rights© 2016 Casquero-Veiga et al.es
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaInformáticaes
dc.subject.ecienciaIngeniería Industriales
dc.subject.ecienciaMaterialeses
dc.subject.ecienciaMedicinaes
dc.subject.ecienciaTelecomunicacioneses
dc.titleResponse to deep brain stimulation in three brain targets with implications in mental disorders: a PET study in ratsen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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