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Skin-on-a-chip models: General overview and future perspectives

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Tissue Engineering and Regenerative Medicine (TERMeG)es
dc.contributor.authorRisueño Rojo, Ignacio
dc.contributor.authorValencia Blanco, Leticia
dc.contributor.authorJorcano Noval, José Luis
dc.contributor.authorVelasco Bayón, Diego
dc.contributor.funderComunidad de Madrides
dc.date.accessioned2021-09-30T11:02:10Z
dc.date.available2021-09-30T11:02:10Z
dc.date.issued2021-09
dc.description.abstractOver the last few years, several advances have been made toward the development and production of in vitro human skin models for the analysis and testing of cosmetic and pharmaceutical products. However, these skin models are cultured under static conditions that make them unable to accurately represent normal human physiology. Recent interest has focused on the generation of in vitro 3D vascularized skin models with dynamic perfusion and microfluidic devices known as skin-on-a-chip. These platforms have been widely described in the literature as good candidates for tissue modeling, as they enable a more physiological transport of nutrients and permit a high-throughput and less expensive evaluation of drug candidates in terms of toxicity, efficacy, and delivery. In this Perspective, recent advances in these novel platforms for the generation of human skin models under dynamic conditions for in vitro testing are reported. Advances in vascularized human skin equivalents (HSEs), transferred skin-on-a-chip (introduction of a skin biopsy or a HSE in the chip), and in situ skin-on-a-chip (generation of the skin model directly in the chip) are critically reviewed, and currently used methods for the introduction of skin cells in the microfluidic chips are discussed. An outlook on current applications and future directions in this field of research are also presented.en
dc.description.sponsorshipThis work was supported by the Programa de Actividades de I+D entre Grupos de Investigación de la Comunidad de Madrid, S2018/BAA-4480, Biopieltec-CM, and Cátedra Fundación Ramón Areces.en
dc.format.extent12
dc.identifier.bibliographicCitationRisueño, I., Valencia, L., Jorcano, J. L. & Velasco, D. (2021). Skin-on-a-chip models: General overview and future perspectives. APL Bioengineering, 5(3), 030901.en
dc.identifier.doihttps://doi.org/10.1063/5.0046376
dc.identifier.issn2473-2877
dc.identifier.publicationfirstpage030901
dc.identifier.publicationissue3
dc.identifier.publicationtitleAPL Bioengineeringen
dc.identifier.publicationvolume5
dc.identifier.urihttps://hdl.handle.net/10016/33346
dc.identifier.uxxiAR/0000028400
dc.language.isoengen
dc.publisherAIP Publishingen
dc.relation.ispartofhttp://hdl.handle.net/10016/34734
dc.relation.projectIDComunidad de Madrid. S2018/BAA-4480es
dc.rights© 2021 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.titleSkin-on-a-chip models: General overview and future perspectivesen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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