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Clickable polymer ligand-functionalized iron oxide nanocubes: A promising nanoplatform for 'local hot spots' magnetically triggered drug release

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dc.affiliation.dptoUC3M. Departamento de Ciencia e Ingeniería de Materiales e Ingeniería Químicaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Polímeros y Compositeses
dc.contributor.authorMai, Binh T.
dc.contributor.authorConteh, John S.
dc.contributor.authorGavilán, Helena
dc.contributor.authorGirolamo, Alessandro Di
dc.contributor.authorPellegrino, Teresa
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2023-05-23T07:01:11Z
dc.date.available2023-05-23T07:01:11Z
dc.date.issued2022-11-02
dc.description.abstractExploiting the local heat on the surface of magnetic nanoparticles (MNPs) upon exposure to an alternating magnetic field (AMF) to cleave thermal labile bonds represents an interesting approach in the context of remotely triggered drug delivery. Here, taking advantages of a simple and scalable two-step ligand exchange reaction, we have prepared iron oxide nanocubes (IONCs) functionalized with a novel multifunctional polymer ligand having multiple catechol moieties, furfuryl pendants, and polyethylene glycol (PEG) side chains. Catechol groups ensure a strong binding of the polymer ligands to the IONCs surface, while the PEG chains provide good colloidal stability to the polymer-coated IONCs. More importantly, furfuryl pendants on the polymer enable to click the molecules of interest (either maleimide–fluorescein or maleimide–doxorubicin) via a thermal labile Diels–Alder adduct. The resulting IONCs functionalized with a fluorescein/doxorubicin-conjugated polymer ligand exhibit good colloidal stability in buffer saline and serum solution along with outstanding heating performance in aqueous solution or even in viscous media (81% glycerol/water) when exposed to the AMF of clinical use. The release of conjugated bioactive molecules such as fluorescein and doxorubicin could be boosted by applying AMF conditions of clinical use (16 kAm–1 and 110 kHz). It is remarkable that the magnetic hyperthermia-mediated release of the dye/drug falls in the concentration range 1.0–5.0 μM at an IONCs dose as low as 0.5 gFe/L and at no macroscopical temperature change. This local release effect makes this magnetic nanoplatform a potential tool for drug delivery with remote magnetic hyperthermia actuation and with a dose-independent action of MNPs.en
dc.description.sponsorshipThis work was partially supported by the Marie Sklodowska-Curie Innovative training network MSCA-ITN-ETN (HeatNMof project, GA 860942), partially by the AIRC Foundation (AIRC IG-14527 to T.P.), partially by the European Research Council (starting grant ICARO, Contract No. 678109), and partially by ERC proof of concept Hypercube, Contract No. 899661).en
dc.format.extent13
dc.identifier.bibliographicCitationMai, B. T., Conteh, J., Gavilán, H., Di Girolamo, A., & Pellegrino, T. (2022). Clickable Polymer Ligand-Functionalized Iron Oxide Nanocubes: A Promising Nanoplatform for ‘Local Hot Spots’ Magnetically Triggered Drug Release. ACS Applied Materials & Interfaces, 14(43), 48476-48488.en
dc.identifier.doihttp://dx.doi.org/10.1021/acsami.2c14752
dc.identifier.issn1944-8244
dc.identifier.publicationfirstpage48476
dc.identifier.publicationissue43
dc.identifier.publicationlastpage48488
dc.identifier.publicationtitleACS Applied Materials & Interfacesen
dc.identifier.publicationvolume14
dc.identifier.urihttps://hdl.handle.net/10016/37331
dc.identifier.uxxiAR/0000032853
dc.language.isoeng
dc.publisherACS Publicationsen
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/860942en
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/678109en
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/899661en
dc.rights© 2022 The Authors.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaIngeniería Industriales
dc.subject.ecienciaIngeniería Mecánicaes
dc.subject.ecienciaMaterialeses
dc.subject.ecienciaQuímicaes
dc.subject.otherMultifunctional polymeren
dc.subject.otherHeat-mediated releaseen
dc.subject.otherMagnetic hyperthermiaen
dc.subject.otherIron oxide nanoparticlesen
dc.subject.otherDrug releaseen
dc.subject.otherHot-spot effecten
dc.titleClickable polymer ligand-functionalized iron oxide nanocubes: A promising nanoplatform for 'local hot spots' magnetically triggered drug releaseen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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