Publication:
Lidocaine-loaded solid lipid microparticles (SLMPs) produced from gas-saturated solutions for wound applications

Simple item page
dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Tissue Engineering and Regenerative Medicine (TERMeG)es
dc.contributor.authorLópez-Iglesias, Clara
dc.contributor.authorQuílez López, Cristina
dc.contributor.authorBarros, Joana
dc.contributor.authorVelasco Bayón, Diego
dc.contributor.authorÁlvarez-Lorenzo, Carmen
dc.contributor.authorJorcano Noval, José Luis
dc.contributor.authorMonteiro, Fernando J.
dc.contributor.authorGarcía-González, Carlos A.
dc.contributor.funderComunidad de Madrides
dc.contributor.funderMinisterio de Economía y Competitividad (España)es
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es
dc.date.accessioned2021-03-15T14:57:31Z
dc.date.available2021-03-15T14:57:31Z
dc.date.issued2020-09-12
dc.descriptionThis research was funded by Xunta de Galicia [ED431F 2016/010], MCIUN [RTI2018-094131-A-I00], Agrupación Estratégica de Materiales [AeMAT-BIOMEDCO2, ED431E 2018/08], Agencia Estatal de Investigación [AEI] and FEDER funds. C.A.G.-G. acknowledges to MINECO for a Ramón y Cajal Fellowship [RYC2014-15239]. This work was partially supported by Programa de Actividades de I+D entre Grupos de Investigación de la Comunidad de Madrid [S2018/BAA-4480, Biopieltec-CM], Programa Estatal de I+D+I Orientada a los Retos de la Sociedad [RTI2018-101627-B-I00] and Cátedra Fundación Ramón Areces.en
dc.description.abstractThe delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound complications. In this work, solid lipid microparticles (SLMPs) loaded with lidocaine hydrochloride (LID) were processed and the formulation was evaluated regarding its ability to deliver the drug at the wound site and through the skin barrier. The SLMPs of glyceryl monostearate (GMS) were prepared with different LID contents (0, 1, 2, 4, and 10 wt.%) using the solvent-free and one-step PGSS (Particles from Gas-Saturated Solutions) technique. PGSS exploits the use of supercritical CO2 (scCO2) as a plasticizer for lipids and as pressurizing agent for the atomization of particles. The SLMPs were characterized in terms of shape, size, and morphology (SEM), physicochemical properties (ATR-IR, XRD), and drug content and release behavior. An in vitro test for the evaluation of the influence of the wound environment on the LID release rate from SLMPs was studied using different bioengineered human skin substitutes obtained by 3D-bioprinting. Finally, the antimicrobial activity of the SLMPs was evaluated against three relevant bacteria in wound infections (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa). SLMPs processed with 10 wt.% of LID showed a remarkable performance to provide effective doses for pain relief and preventive infection effects.en
dc.format.extent16es
dc.identifier.bibliographicCitationPharmaceutics 2020, 12(9), 870, 16 pp.en
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics12090870
dc.identifier.issn1999-4923
dc.identifier.publicationfirstpage1es
dc.identifier.publicationissue9es
dc.identifier.publicationlastpage16es
dc.identifier.publicationtitlePharmaceuticsen
dc.identifier.publicationvolume12es
dc.identifier.urihttps://hdl.handle.net/10016/32145
dc.identifier.uxxiAR/0000027380
dc.language.isoengen
dc.publisherMDPIen
dc.relation.projectIDComunidad de Madrid. S2018/BAA-4480es
dc.relation.projectIDGobierno de España. RTI2018-101627-B-I00es
dc.relation.projectIDGobierno de España. RTI2018-094131-A-I00es
dc.relation.projectIDGobierno de España. RYC2014-15239es
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY)en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.titleLidocaine-loaded solid lipid microparticles (SLMPs) produced from gas-saturated solutions for wound applicationsen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
lidocaine_PHARMACEUTICS_2020.pdf
Size:
2.72 MB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
lidocaine_PHARMACEUTICS_2020_Supplementary material.pdf
Size:
323.53 KB
Format:
Adobe Portable Document Format
Download
Collections
DBIAB - TERMEG - Journal Articles