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The Antimicrobial Activity of Micron-Thin Sol-Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections

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dc.affiliation.dptoUC3M. Departamento de Ciencia e Ingeniería de Materiales e Ingeniería Químicaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Tecnología de Polvoses
dc.contributor.authorToirac Chavez, Beatriz Duniaes
dc.contributor.authorAguilera-Correa, John Jairoes
dc.contributor.authorMediero, Aranzazues
dc.contributor.authorEsteban, Jaimees
dc.contributor.authorJiménez Morales, Antoniaes
dc.contributor.funderComunidad de Madrides
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (España)es
dc.date.accessioned2023-11-10T17:38:37Z
dc.date.available2023-11-10T17:38:37Z
dc.date.issued2023-03-01
dc.description.abstractOrthopedic prosthesis-related infections (OPRI) are an essential health concern. OPRI prevention is a priority and a preferred option over dealing with poor prognosis and high-cost treatments. Micron-thin sol–gel films have been noted for a continuous and effective local delivery system. This study aimed to perform a comprehensive in vitro evaluation of a novel hybrid organic–inorganic sol–gel coating developed from a mixture of organopolysiloxanes and organophosphite and loaded with different concentrations of linezolid and/or cefoxitin. The kinetics of degradation and antibiotics release from the coatings were measured. The inhibition of biofilm formation of the coatings against Staphylococcus aureus, S. epidermidis, and Escherichia coli strains was studied, as well as the cell viability and proliferation of MC3T3-E1 osteoblasts. The microbiological assays demonstrated that sol–gel coatings inhibited the biofilm formation of the evaluated Staphylococcus species; however, no inhibition of the E. coli strain was achieved. A synergistic effect of the coating loaded with both antibiotics was observed against S. aureus. The cell studies showed that the sol–gels did not compromise cell viability and proliferation. In conclusion, these coatings represent an innovative therapeutic strategy with potential clinical use to prevent staphylococcal OPRI.en
dc.description.sponsorshipFunding: This research was funded by the Regional Government of Madrid through the program ADITIMAT (ref. P2018/NMT-4411) and CIBERINFEC-CIBER of Infectious Diseases (CB21/13/00043). B.T. would like to thank the Spanish Ministry of Education, Culture, and Sports for the support through the FPU grant (FPU17/05977).en
dc.description.statusPublicadoes
dc.format.extent19
dc.identifier.bibliographicCitationToirac B, Aguilera-Correa JJ, Mediero A, Esteban J, Jiménez-Morales A. The Antimicrobial Activity of Micron-Thin Sol–Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infections. Gels. 2023; 9(3):176, (19p.). https://doi.org/10.3390/gels9030176en
dc.identifier.doihttps://doi.org/10.3390/gels9030176en
dc.identifier.issn2310-2861
dc.identifier.publicationfirstpage1
dc.identifier.publicationissue3, 176
dc.identifier.publicationlastpage19
dc.identifier.publicationtitleGelsen
dc.identifier.publicationvolume9
dc.identifier.urihttps://hdl.handle.net/10016/38833en
dc.identifier.uxxiAR/0000033465
dc.language.isoengen
dc.publisherMDPIen
dc.relation.projectIDComunidad de Madrid. P2018/NMT-4411/ADITIMATes
dc.relation.projectIDComunidad de Madrid. CB21/13/00043/CIBERINFEC-CIBERes
dc.relation.projectIDGobierno de España. FPU17/05977es
dc.rights© 2023 by the authors.en
dc.rightsLicensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseen
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.ecienciaMaterialeses
dc.subject.ecienciaQuímicaes
dc.subject.otherCefoxitinen
dc.subject.otherElectrochemical Impedance Spectroscopyen
dc.subject.otherEscherichia Colien
dc.subject.otherLinezoliden
dc.subject.otherNanogelsen
dc.subject.otherProsthesis-Related Infectionsen
dc.subject.otherSol-Gel Coatingen
dc.subject.otherStaphylococcus Aureusen
dc.subject.otherStaphylococcus Epidermidisen
dc.titleThe Antimicrobial Activity of Micron-Thin Sol-Gel Films Loaded with Linezolid and Cefoxitin for Local Prevention of Orthopedic Prosthesis-Related Infectionsen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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