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Experimental validation of gallium production and isotope-dependent positron range correction in PET

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédicaes
dc.contributor.authorFraile, L.M.
dc.contributor.authorHerraiz, J.L
dc.contributor.authorUdías, José Manuel
dc.contributor.authorCal González, Jacobo
dc.contributor.authorCorzo, P.M.G
dc.contributor.authorEspaña, Samuel
dc.contributor.authorHerranz, Elena
dc.contributor.authorPérez Liva, M.
dc.contributor.authorPicado, E.
dc.contributor.authorMuñoz Martín, A.
dc.contributor.authorVaquero López, Juan José
dc.contributor.authorVicente, Esther
dc.date.accessioned2016-02-09T08:50:28Z
dc.date.available2018-04-30T22:00:05Z
dc.date.issued2016-04
dc.description.abstractPositron range (PR) is one of the important factors that limit the spatial resolution of positron emission tomography (PET) preclinical images. Its blurring effect can be corrected to a large extent if the appropriate method is used during the image reconstruction. Nevertheless, this correction requires an accurate modelling of the PR for the particular radionuclide and materials in the sample under study. In this work we investigate PET imaging with 68Ga and 66Ga radioisotopes, which have a large PR and are being used in many preclinical and clinical PET studies. We produced a 68Ga and 66Ga phantom on a natural zinc target through (p,n) reactions using the 9-MeV proton beam delivered by the 5-MV CMAM tandetron accelerator. The phantom was imaged in an ARGUS small animal PET/CT scanner and reconstructed with a fully 3D iterative algorithm, with and without PR corrections. The reconstructed images at different time frames show significant improvement in spatial resolution when the appropriate PR is applied for each frame, by taking into account the relative amount of each isotope in the sample. With these results we validate our previously proposed PR correction method for isotopes with large PR. Additionally, we explore the feasibility of PET imaging with 68Ga and 66Ga radioisotopes in proton therapy.en
dc.description.sponsorshipWe acknowledge support from the Spanish MINECO through projects FPA2010-17142, FPA2013-41267-P, CSD-2007-00042 (CPAN), and the RTC-2015-3772-1 grant. We also acknowledge support from Comunidad de Madrid via the TOPUS S2013/MIT-3024 project.en
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dc.format.mimetypeapplication/pdf
dc.identifier.bibliographicCitationFraile, L.M et al. (2015). Experimental validation of gallium production and isotope-dependent positron range correction in PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment , v. 814, pp. 110–116. DOI:10.1016/j.nima.2016.01.013en
dc.identifier.doihttps://doi.org/10.1016/j.nima.2016.01.013
dc.identifier.issn0168-9002
dc.identifier.publicationfirstpage110
dc.identifier.publicationlastpage116
dc.identifier.publicationtitleNuclear instruments and methods in physics research. Section A: Accelerators, spectrometers, detectors and Associated Equipmenten
dc.identifier.publicationvolume814
dc.identifier.urihttps://hdl.handle.net/10016/22249
dc.identifier.uxxiAR/0000017724
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDComunidad de Madrid. S2013/MIT-3024 TOPUS-CM
dc.relation.projectIDGobierno de España. FPA2010-17142
dc.relation.projectIDGobierno de España. FPA2013-41267-P
dc.relation.projectIDGobierno de España. RTC-2015-3772-1
dc.rights© Elsevier
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.ecienciaMedicinaes
dc.subject.otherRadioisotope productionen
dc.subject.otherPositron emission tomographyen
dc.subject.otherPositron rangeen
dc.subject.other66Gaen
dc.subject.other68Gaen
dc.titleExperimental validation of gallium production and isotope-dependent positron range correction in PETen
dc.typeresearch article*
dc.type.hasVersionAM*
dspace.entity.typePublication
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