Publication: Experimental validation of gallium production and isotope-dependent positron range correction in PET
dc.affiliation.dpto | UC3M. Departamento de Bioingeniería | es |
dc.affiliation.grupoinv | UC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédica | es |
dc.contributor.author | Fraile, L.M. | |
dc.contributor.author | Herraiz, J.L | |
dc.contributor.author | Udías, José Manuel | |
dc.contributor.author | Cal González, Jacobo | |
dc.contributor.author | Corzo, P.M.G | |
dc.contributor.author | España, Samuel | |
dc.contributor.author | Herranz, Elena | |
dc.contributor.author | Pérez Liva, M. | |
dc.contributor.author | Picado, E. | |
dc.contributor.author | Muñoz Martín, A. | |
dc.contributor.author | Vaquero López, Juan José | |
dc.contributor.author | Vicente, Esther | |
dc.date.accessioned | 2016-02-09T08:50:28Z | |
dc.date.available | 2018-04-30T22:00:05Z | |
dc.date.issued | 2016-04 | |
dc.description.abstract | Positron range (PR) is one of the important factors that limit the spatial resolution of positron emission tomography (PET) preclinical images. Its blurring effect can be corrected to a large extent if the appropriate method is used during the image reconstruction. Nevertheless, this correction requires an accurate modelling of the PR for the particular radionuclide and materials in the sample under study. In this work we investigate PET imaging with 68Ga and 66Ga radioisotopes, which have a large PR and are being used in many preclinical and clinical PET studies. We produced a 68Ga and 66Ga phantom on a natural zinc target through (p,n) reactions using the 9-MeV proton beam delivered by the 5-MV CMAM tandetron accelerator. The phantom was imaged in an ARGUS small animal PET/CT scanner and reconstructed with a fully 3D iterative algorithm, with and without PR corrections. The reconstructed images at different time frames show significant improvement in spatial resolution when the appropriate PR is applied for each frame, by taking into account the relative amount of each isotope in the sample. With these results we validate our previously proposed PR correction method for isotopes with large PR. Additionally, we explore the feasibility of PET imaging with 68Ga and 66Ga radioisotopes in proton therapy. | en |
dc.description.sponsorship | We acknowledge support from the Spanish MINECO through projects FPA2010-17142, FPA2013-41267-P, CSD-2007-00042 (CPAN), and the RTC-2015-3772-1 grant. We also acknowledge support from Comunidad de Madrid via the TOPUS S2013/MIT-3024 project. | en |
dc.format.extent | 8 | |
dc.format.mimetype | application/pdf | |
dc.identifier.bibliographicCitation | Fraile, L.M et al. (2015). Experimental validation of gallium production and isotope-dependent positron range correction in PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment , v. 814, pp. 110–116. DOI:10.1016/j.nima.2016.01.013 | en |
dc.identifier.doi | https://doi.org/10.1016/j.nima.2016.01.013 | |
dc.identifier.issn | 0168-9002 | |
dc.identifier.publicationfirstpage | 110 | |
dc.identifier.publicationlastpage | 116 | |
dc.identifier.publicationtitle | Nuclear instruments and methods in physics research. Section A: Accelerators, spectrometers, detectors and Associated Equipment | en |
dc.identifier.publicationvolume | 814 | |
dc.identifier.uri | https://hdl.handle.net/10016/22249 | |
dc.identifier.uxxi | AR/0000017724 | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.projectID | Comunidad de Madrid. S2013/MIT-3024 TOPUS-CM | |
dc.relation.projectID | Gobierno de España. FPA2010-17142 | |
dc.relation.projectID | Gobierno de España. FPA2013-41267-P | |
dc.relation.projectID | Gobierno de España. RTC-2015-3772-1 | |
dc.rights | © Elsevier | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | |
dc.subject.eciencia | Medicina | es |
dc.subject.other | Radioisotope production | en |
dc.subject.other | Positron emission tomography | en |
dc.subject.other | Positron range | en |
dc.subject.other | 66Ga | en |
dc.subject.other | 68Ga | en |
dc.title | Experimental validation of gallium production and isotope-dependent positron range correction in PET | en |
dc.type | research article | * |
dc.type.hasVersion | AM | * |
dspace.entity.type | Publication |
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