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Real-time ventricular cancellation in unipolar atrial fibrillation electrograms

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dc.affiliation.dptoUC3M. Departamento de Teoría de la Señal y Comunicacioneses
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Tratamiento de la Señal y Aprendizaje (GTSA)es
dc.contributor.authorRíos Muñoz, Gonzalo Ricardo
dc.contributor.authorArtés Rodríguez, Antonio
dc.contributor.authorFernández-Avilés, Francisco
dc.contributor.authorArenal, Ángel
dc.contributor.funderComunidad de Madrides
dc.date.accessioned2021-05-12T11:44:51Z
dc.date.available2021-05-12T11:44:51Z
dc.date.issued2020-07-30
dc.description.abstractUnipolar atrial fibrillation (AF) electrograms (EGMs) require far-field ventricle cancellation to recover hidden atrial activations. Current methods cannot achieve real-time cancellation because of the temporal delay they introduce. We propose a new real-time ventricular cancellation (RVC) method based on causal implementation optimized for real-time functioning. The method is similar to the classical average beat subtraction (ABS) method but it computes the ventricular contribution before the ventricular activation finishes. We compare the proposed method to the ABS on synthetic and real EGM databases for the time and frequency domains. All parameters and their optimal values are analyzed and validated. The RVC method provides a good reconstruction of the unipolar EGMs and a better local activation time detection than the classical approach with average F1scores 0.7307 and 0.7125, respectively. The spectral analysis shows that the average power after ventricular cancellation is reduced for frequency bands between 3 and 5.5 Hz, demonstrating that the proposed method removes the ventricular component present in the unipolar EGM signals compared to the ABS method. The phase mapping analysis on the RVC method presented lower error when comparing the annotated EGM cycles with the phase inversion intervals. In terms of performance ABS and RVC behave similarly, but the real-time capability of the latter justifies its preference over the offline implementations. In the clinical environment other online investigations, e.g., rotational activity assessment, dominant frequency or local activation time mapping, might benefit from the real-time potential of the proposed cancellation method.en
dc.description.sponsorshipThis study was supported by grants PI18/01895 from the Instituto de Salud Carlos III, and RD16/0011/0029 Red de Terapia Celular from the Instituto de Salud Carlos III, projects RTI2018-099655-B-I00; TEC2017-92552-EXP from Ministerio de Ciencia, Innovación y Universidades, Y2018/TCS-4705, PRACTICO-CM Comunidad de Madrid, and the support of NVIDIA Corporation with the donation of the Titan V GPU used during this research.en
dc.format.extent14es
dc.identifier.bibliographicCitationFrontiers in bioengineering and biotechnology, 8, article 789, July 2020, 14 pp.en
dc.identifier.doihttps://doi.org/10.3389/fbioe.2020.00789
dc.identifier.issn2296-4185
dc.identifier.publicationfirstpage1es
dc.identifier.publicationissuearticle 789es
dc.identifier.publicationlastpage14es
dc.identifier.publicationtitleFrontiers in Bioengineering and Biotechnologyen
dc.identifier.publicationvolume8es
dc.identifier.urihttps://hdl.handle.net/10016/32611
dc.identifier.uxxiAR/0000026791
dc.language.isoengen
dc.publisherFrontiersen
dc.relation.projectIDGobierno de España. TEC2017-92552-EXPes
dc.relation.projectIDGobierno de España. RTI2018-099655-B-I00es
dc.relation.projectIDComunidad de Madrid. Y2018/TCS-4705es
dc.rights© 2020 Ríos-Muñoz, Artés-Rodríguez, Fernández-Avilés and Arenal.en
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaElectrónicaes
dc.subject.otherAtrial fibrillationen
dc.subject.otherUnipolar electrogramsen
dc.subject.otherReal-timeen
dc.subject.otherBiomedical signal processingen
dc.subject.otherMulti-electrode catheteren
dc.titleReal-time ventricular cancellation in unipolar atrial fibrillation electrogramses
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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