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Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Groupes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédicaes
dc.contributor.authorGarcía Vázquez, Verónica
dc.contributor.authorCalvo, Felipe A
dc.contributor.authorLedesma Carbayo, María Jesús
dc.contributor.authorVicente Solé, Claudio
dc.contributor.authorCalvo Haro, José Antonio
dc.contributor.authorDesco Menéndez, Manuel
dc.contributor.authorPascau González-Garzón, Javier
dc.contributor.funderMinisterio de Economía y Competitividad (España)es
dc.date.accessioned2021-02-12T09:12:47Z
dc.date.available2021-02-12T09:12:47Z
dc.date.issued2020-01-10
dc.description.abstractIn intraoperative electron radiation therapy (IOERT) the energy of the electron beam is selected under the conventional assumption of water-equivalent tissues at the applicator end. However, the treatment field can deviate from the theoretic flat irradiation surface, thus altering dose profiles. This patient-based study explored the feasibility of acquiring intraoperative computed tomography (CT) studies for calculating three-dimensional dose distributions with two factors not included in the conventional assumption, namely the air gap from the applicator end to the irradiation surface and tissue heterogeneity. In addition, dose distributions under the conventional assumption and from preoperative CT studies (both also updated with intraoperative data) were calculated to explore whether there are other alternatives to intraoperative CT studies that can provide similar dose distributions. The IOERT protocol was modified to incorporate the acquisition of intraoperative CT studies before radiation delivery in six patients.en
dc.description.sponsorshipThis study was supported by Ministerio de Ciencia, Innovación y Universidades (http://www.ciencia.gob.es) [grant number TEC2013–48251-C2 to JP, VG-V and MJL-C], co-funded by European Regional Development Fund (ERDF), “A way of making Europe” (https://ec.europa.eu/regional_policy/en/funding/erdf); by Ministerio de Ciencia, Innovación y Universidades (http://www.ciencia.gob.es), Instituto de Salud Carlos III (https://www.isciii.es) [grant numbers DTS14/00192 to JP, VG-V and FAC; PI15/02121 to FAC and JC-H; PI18/01625 to JP], co-funded by European Regional Development Fund (ERDF), “A way of making Europe” (https://ec.europa.eu/regional_policy/en/funding/erdf); and by Comunidad de Madrid (http://www.comunidad.madrid) [grant number TOPUS-CM S2013/MIT3024 to JP], co-funded by European Structural and Investment Fund (https://ec.europa.eu/info/funding-tenders/funding-opportunities/funding-programmes/overview-funding-programmes_en). The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades (http://www.ciencia.gob.es) and the Pro CNIC Foundation (https://www.fundacionprocnic.es) [to MD], and is a Severo Ochoa Center of Excellence (SEV-2015-0505). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extent12
dc.identifier.bibliographicCitationGarcía-Vázquez V, Calvo FA, Ledesma-Carbayo MJ, Sole CV, Calvo-Haro J, Desco M, et al. (2020) Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations. PLoS ONE 15(1): e0227155
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0227155
dc.identifier.issn1932-6203
dc.identifier.publicationissue1(e0227155)
dc.identifier.publicationtitlePLoS One
dc.identifier.publicationvolume15
dc.identifier.urihttps://hdl.handle.net/10016/31915
dc.identifier.uxxiAR/0000024190
dc.language.isoeng
dc.publisherPLOS
dc.relation.datasethttps://www.doi.org/10.6084/m9.figshare.9248897
dc.relation.projectIDGobierno de España. TEC2013-48251-C2-1-R
dc.rights© 2020 García-Vázquez et al.
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.otherComputed axial tomographyen
dc.subject.otherTissue distributionen
dc.subject.otherSurgical and invasive medical proceduresen
dc.subject.otherBreast canceren
dc.subject.otherRadiation therapyen
dc.subject.otherCancer treatmenten
dc.subject.otherImage processingen
dc.subject.otherSurgical oncologyen
dc.titleIntraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observationsen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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