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Alpha band disruption in the AD-continuum starts in the subjective cognitive decline stage: a MEG study

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dc.affiliation.dptoUC3M. Departamento de Informáticaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: COSEC (Computer SECurity Lab)es
dc.contributor.authorLópez Sanz, D.
dc.contributor.authorBruña, R.
dc.contributor.authorGarcés, P.
dc.contributor.authorCámara Núñez, María Carmen
dc.contributor.authorSerrano, N.
dc.contributor.authorRodríguez Rojo, I. C.
dc.contributor.authorDelgado, M. L.
dc.contributor.authorMontenegro, M.
dc.contributor.authorLópez Higes, R.
dc.contributor.authorYus, M.
dc.contributor.authorMaestu, F.
dc.contributor.funderMinisterio de Economía y Competitividad (España)es
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (España)es
dc.date.accessioned2023-11-30T10:54:24Z
dc.date.available2023-11-30T10:54:24Z
dc.date.issued2016-11-24
dc.description.abstractThe consideration of Subjective Cognitive Decline (SCD) as a preclinical stage of AD remains still a matter of debate. Alpha band alterations represent one of the most significant changes in the electrophysiological profile of AD. In particular, AD patients exhibit reduced alpha relative power and frequency. We used alpha band activity measured with MEG to study whether SCD and MCI elders present these electrophysiological changes characteristic of AD, and to determine the evolution of the observed alterations across AD spectrum. The total sample consisted of 131 participants: 39 elders without SCD, 41 elders with SCD and 51 MCI patients. All of them underwent MEG and MRI scans and neuropsychological assessment. SCD and MCI patients exhibited a similar reduction in alpha band activity compared with the no SCD group. However, only MCI patients showed a slowing in their alpha peak frequency compared with both SCD and no SCD. These changes in alpha band were related to worse cognition. Our results suggest that AD-related alterations may start in the SCD stage, with a reduction in alpha relative power. It is later, in the MCI stage, where the slowing of the spectral profile takes place, giving rise to objective deficits in cognitive functioning.en
dc.description.sponsorshipThis study was supported by two projects from the Spanish Ministry of Economy and Competitiveness, PSI2009-14415-C03-01 and PSI2012-38375-C03-01, a predoctoral fellowship from the Ministry of Economy and Competitiveness to DLS (PSI2012-38375-C03-01), and three predoctoral fellowships from the Ministry of Education to RB,NS,ICRR (FPU13/06009, FPU14/07164, FPU13/02064).en
dc.format.extent11
dc.identifier.bibliographicCitationLópez-Sanz, D., Bruña, R., Garcés, P. et al (2016). Alpha band disruption in the AD-continuum starts in the Subjective Cognitive Decline stage: a MEG study. Scientific Reports, 6, 37685.en
dc.identifier.doi10.1038/srep37685
dc.identifier.issn2045-2322
dc.identifier.publicationfirstpage1
dc.identifier.publicationissue6, 37685
dc.identifier.publicationlastpage11
dc.identifier.publicationtitleScientific Reportsen
dc.identifier.urihttps://hdl.handle.net/10016/39007
dc.identifier.uxxiAR/0000024592
dc.language.isoengen
dc.publisherSpringer Natureen
dc.relation.projectIDGobierno de España. PSI2009-14415-C03-01es
dc.relation.projectIDGobierno de España. PSI2012-38375-C03-01es
dc.relation.projectIDGobierno de España. FPU13/06009es
dc.relation.projectIDGobierno de España. FPU14/07164es
dc.relation.projectIDGobierno de España. FPU13/02064es
dc.rights© The Author(s) 2016.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaElectrónicaes
dc.subject.ecienciaInformáticaes
dc.titleAlpha band disruption in the AD-continuum starts in the subjective cognitive decline stage: a MEG studyen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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