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Effects of cardiac stem cell on postinfarction arrhythmogenic substrate

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dc.affiliation.dptoUC3M. Departamento de Teoría de la Señal y Comunicacioneses
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Tratamiento de la Señal y Aprendizaje (GTSA)es
dc.contributor.authorArenal, Ángel
dc.contributor.authorRíos Muñoz, Gonzalo Ricardo
dc.contributor.authorCarta-Bergaz, Alejandro
dc.contributor.authorRuiz Hernández, Pablo M.
dc.contributor.authorPerez David, Esther
dc.contributor.authorCrisostomo, Veronica
dc.contributor.authorLoughlin, Gerard
dc.contributor.authorSanz Ruiz, Ricardo
dc.contributor.authorFernandez Portales, Javier
dc.contributor.authorAcosta, Alejandra
dc.contributor.authorBaez Diaz, Claudia
dc.contributor.authorBlanco Blázquez, Virginia
dc.contributor.authorLedesma-Carbayo, María J.
dc.contributor.authorPareja, Miriam
dc.contributor.authorFernandez Santos, Maria E.
dc.contributor.authorSánchez-Margallo, Francisco M.
dc.contributor.authorCasado, Javier G.
dc.contributor.authorFernández-Avilés, Francisco
dc.contributor.funderEuropean Commissiones
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es
dc.date.accessioned2023-02-15T11:04:25Z
dc.date.available2023-02-15T11:04:25Z
dc.date.issued2022-12-02
dc.descriptionThis article belongs to the Special Issue New Insights into Cardiovascular Diseases in Basic Research.en
dc.description.abstractClinical data suggest that cardiosphere-derived cells (CDCs) could modify post-infarction scar and ventricular remodeling and reduce the incidence of ventricular tachycardia (VT). This paper assesses the effect of CDCs on VT substrate in a pig model of postinfarction monomorphic VT. We studied the effect of CDCs on the electrophysiological properties and histological structure of dense scar and heterogeneous tissue (HT). Optical mapping and histological evaluation were performed 16 weeks after the induction of a myocardial infarction by transient occlusion of the left anterior descending (LAD) artery in 21 pigs. Four weeks after LAD occlusion, pigs were randomized to receive intracoronary plus trans-myocardial CDCs (IC+TM group, n: 10) or to a control group. Optical mapping (OM) showed an action potential duration (APD) gradient between HT and normal tissue in both groups. CDCs increased conduction velocity (53 ± 5 vs. 45 ± 6 cm/s, p < 0.01), prolonged APD (280 ± 30 ms vs. 220 ± 40 ms, p < 0.01) and decreased APD dispersion in the HT. During OM, a VT was induced in one and seven of the IC+TM and control hearts (p = 0.03), respectively; five of these VTs had their critical isthmus located in intra-scar HT found adjacent to the coronary arteries. Histological evaluation of HT revealed less fibrosis (p < 0.01), lower density of myofibroblasts (p = 0.001), and higher density of connexin-43 in the IC+TM group. Scar and left ventricular volumes did not show differences between groups. Allogeneic CDCs early after myocardial infarction can modify the structure and electrophysiology of post-infarction scar. These findings pave the way for novel therapeutic properties of CDCs.en
dc.description.sponsorshipThis study was funded by the National Fund for Health Research (Fondo de Investigación Sanitaria) from the Spanish Ministry of Science and Innovation, Spain [PI10/02771, TIN2007-68048-C02-01, TIN2007-68048-C02-02, PI13-01882, PI13-00903, PI13/02858, IJCI-2014-22178, TEC2010-21619-C04-03]; the Cooperative Cardiovascular Disease Research Network RIC [RD12/0042/0001]; the Instituto de Salud Carlos III, Madrid, Spain (PI18/01895 and DTS21/00064); Red de Terapia Celular from the Instituto de Salud Carlos III, Madrid, Spain (RD16/0011/0029, RD12/0019/0021); the European Union's H2020 Program under grant agreement No. 874827 (BRAVE); and Ricors-Red de Investigación Cooperativa Orientada a Resultados en Salud RICORS TERAV (RD21.0017.0002). Proyecto de Investigación translacional 2019 de la Sociedad Española de Cardiología (Caracterización del sustrato arrítmico epicárdico en un modelo porcino de taquicardia ventricular post-infarto).en
dc.format.extent18
dc.identifier.bibliographicCitationArenal, N. et al. (2022). Effects of Cardiac Stem Cell on Postinfarction Arrhythmogenic Substrate. International Journal of Molecular Sciences, 23(24), 16211.en
dc.identifier.doihttps://doi.org/10.3390/ijms232416211
dc.identifier.issn1661-6596
dc.identifier.publicationfirstpage1
dc.identifier.publicationissue24, 16211
dc.identifier.publicationlastpage18
dc.identifier.publicationtitleInternational Journal of Molecular Sciencesen
dc.identifier.publicationvolume23
dc.identifier.urihttps://hdl.handle.net/10016/36574
dc.identifier.uxxiAR/0000031625
dc.language.isoeng
dc.publisherMDPIen
dc.relation.projectIDGobierno de España. PI10/02771es
dc.relation.projectIDGobierno de España. TIN2007-68048-C02-01es
dc.relation.projectIDGobierno de España. TIN2007-68048-C02-02es
dc.relation.projectIDGobierno de España. PI13-01882es
dc.relation.projectIDGobierno de España. PI13-00903es
dc.relation.projectIDGobierno de España. PI13/02858es
dc.relation.projectIDGobierno de España. IJCI-2014-22178es
dc.relation.projectIDGobierno de España. TEC2010-21619-C04-03es
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/ GA-874827
dc.rights© 2022 by the authors.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaTelecomunicacioneses
dc.subject.otherStem cellsen
dc.subject.otherVentricular arhythmiasen
dc.subject.otherPost-infarction scaren
dc.subject.otherVentricular tachycardiaen
dc.subject.otherCardiosphere-derived cellsen
dc.subject.otherElectrophysiologyen
dc.titleEffects of cardiac stem cell on postinfarction arrhythmogenic substrateen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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