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Resolution uniformity and sensitivity of the NIH ATLAS small animal PET scanner: comparison to simulated LSO scanners without depth-of-interaction capability

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédicaes
dc.contributor.authorSeidel, Jürgen
dc.contributor.authorVaquero López, Juan José
dc.contributor.authorGreen, Michael V.
dc.date.accessioned2011-09-19T12:51:41Z
dc.date.available2011-09-19T12:51:41Z
dc.date.issued2001
dc.descriptionProceeding of: 2001 Nuclear Science Symposium and Medical Imaging Conference, november 4-10, 2001, San Diego, California
dc.description.abstractPET scanners designed to image animals the size of rats and mice should possess simultaneously high and uniform spatial resolution and high sensitivity. ATLAS (Advanced Technology Laboratory Animal Scanner), an 11.8 cm diameter aperture, 2 cm axial field-of-view ring-type research scanner seeks these goals by surrounding the animal with eighteen 15 mm deep, LGSO (7 mm) / GSO (8 mm) phoswich detector modules. A Monte Carlo simulation was used to compare the variation of resolution across the field-of-view and the absolute central point source sensitivity (ACS) of ATLAS to similar systems comprised only of LSO arrays of different depths with no depth-of-interaction (DOI) capability. For ATLAS radial spatial resolution deteriorated by 27% from the center to 3 cm off-axis. Scanners comprised of 15 mm deep, 10 mm deep and 7 mm deep LSO crystals deteriorated by 100%, 51%, and 20% respectively, over the same distance. Simulated ACS (absorbed energies > 250 keV) for ATLAS was 2.0% and for the 15 mm, 10 mm deep and 7 mm deep LSO scanners 2.4%, 1.5%, and 0.9%, respectively. Radial resolution loss 3 cm off-axis and ACS measured for the actual ATLAS scanner were similar to the values obtained by simulation (27% resolution loss, 1.8% ACS). The phoswich design thus achieves good resolution uniformity over a 6 cm FOV while preserving sensitivity compared to equivalent non-DOI LSO scanners with a range of crystal depths.
dc.description.statusPublicado
dc.format.mimetypeapplication/pdf
dc.identifier.bibliographicCitation2001 IEEE Nuclear Science Symposium Conference Record, 2001, n. 3, p. 1555-1558
dc.identifier.doi10.1109/NSSMIC.2001.1008634
dc.identifier.isbn0-7803-7324-3
dc.identifier.issn1082-3654
dc.identifier.publicationfirstpage1555
dc.identifier.publicationissue3
dc.identifier.publicationlastpage1558
dc.identifier.publicationtitle2001 IEEE Nuclear Science Symposium Conference Record
dc.identifier.urihttps://hdl.handle.net/10016/12110
dc.language.isoeng
dc.publisherIEEE
dc.relation.eventdateNovember 4-10, 2001
dc.relation.eventplaceSan Diego, California
dc.relation.eventtitle2001 Nuclear Science Symposium and Medical Imaging Conference
dc.relation.hasversionhttp://e-archivo.uc3m.es/handle/10016/9358
dc.relation.publisherversionhttp://dx.doi.org/10.1109/NSSMIC.2001.1008634
dc.rights© IEEE
dc.rights.accessRightsopen access
dc.subject.ecienciaBiología y Biomedicina
dc.titleResolution uniformity and sensitivity of the NIH ATLAS small animal PET scanner: comparison to simulated LSO scanners without depth-of-interaction capability
dc.typeconference proceedings*
dc.type.hasVersionAM*
dspace.entity.typePublication
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