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Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Groupes
dc.contributor.authorRomero Miguel, Luis Diego
dc.contributor.authorCasquero-Veiga, Marta
dc.contributor.authorFernández, Javier
dc.contributor.authorLamanna Rama, Nicolás
dc.contributor.authorGómez Rangel, Vanessa
dc.contributor.authorGálvez-Robleño, Carlos
dc.contributor.authorSanta Marta, Cristina
dc.contributor.authorVillar, Claudio J.
dc.contributor.authorLombo, Felipe
dc.contributor.authorAbalo, Raquel
dc.contributor.authorDesco Menéndez, Manuel
dc.contributor.authorSoto Montenegro, Mª Luisa
dc.contributor.funderComunidad de Madrides
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es
dc.date.accessioned2023-11-15T13:32:15Z
dc.date.available2023-11-15T13:32:15Z
dc.date.issued2023-04-20
dc.description.abstractThe microbiota-gut-brain axis is a complex interconnected system altered in schizophrenia. The antioxidant N-acetylcysteine (NAC) has been proposed as an adjunctive therapy to antipsychotics in clinical trials, but its role in the microbiota-gut-brain axis has not been sufficiently explored. We aimed to describe the effect of NAC administration during pregnancy on the gut-brain axis in the offspring from the maternal immune stimulation (MIS) animal model of schizophrenia. Pregnant Wistar rats were treated with PolyI:C/Saline. Six groups of animals were studied according to the study factors: phenotype (Saline, MIS) and treatment (no NAC, NAC 7 days, NAC 21 days). Offspring were subjected to the novel object recognition test and were scanned using MRI. Caecum contents were used for metagenomics 16S rRNA sequencing. NAC treatment prevented hippocampal volume reduction and long-term memory deficits in MIS-offspring. In addition, MIS-animals showed lower bacterial richness, which was prevented by NAC. Moreover, NAC7/NAC21 treatments resulted in a reduction of proinflammatory taxons in MIS-animals and an increase in taxa known to produce anti-inflammatory metabolites. Early approaches, like this one, with anti-inflammatory/anti-oxidative compounds, especially in neurodevelopmental disorders with an inflammatory/oxidative basis, may be useful in modulating bacterial microbiota, hippocampal size, as well as hippocampal-based memory impairments.en
dc.description.sponsorshipM.L.S.-M. was supported by the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (project number PI17/01766, and grant number BA21/00030), co-financed by the European Regional Development Fund (ERDF), “A way to make Europe”; project PID2021-128862OB-I00 funded by MCIN/AEI/10.13039/501100011033/FEDER, UE, CIBER de Salud Mental-Instituto de Salud Carlos III (project number CB07/09/0031); Delegación del Gobierno para el Plan Nacional sobre Drogas (project number 2017/085, 2022/008917); and Fundación Alicia Koplowitz. D.R.-M. was supported by Consejería de Educación e investigación, Comunidad de Madrid, co-funded by the European Social Fund “Investing in your future” (grant, PEJD-2018-PRE/BMD-7899). M.C.-V. was supported by a predoctoral grant from Fundación Tatiana Pérez de Guzmán el Bueno. N.L.-R. was supported by the Instituto de investigación Sanitaria Gregorio Marañón, “Programa Intramural de Impulso a la I+D+I 2019”. V.G.-R was supported by Consejería de Educación e investigación, Comunidad de Madrid, co-funded by the European Social Fund “Investing in your future” (grant, PEJD-2017-TL/BMD-7385). C.G.-R. was supported by Universidad Rey Juan Carlos (PREDOC20- 054). R.A. was supported by Ministerio de Ciencia, Innovación y Universidades (grant number PID2019-111510RB-I00) and Grupo Español de Motilidad Digestiva (Beca Allergan, 2017). M.D. work was supported by Ministerio de Ciencia e Innovación (MCIN) and Instituto de Salud Carlos III (PT20/00044). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). J.F. was supported by “Contrato Intramural Postdoctoral” from FINBA (Principado de Asturias, Spain). F.L. was supported by Ayudas para grupos de investigación de organismos del Principado de Asturias (SV-PA-21-AYUD/2021/51347).es
dc.description.statusPublicadoes
dc.format.extent18
dc.identifier.bibliographicCitationAntioxidants 2023, 12(4): 970, (18 p.).en
dc.identifier.doihttps://doi.org/10.3390/antiox12040970
dc.identifier.issn2076-3921
dc.identifier.publicationfirstpage1
dc.identifier.publicationissue4(970)
dc.identifier.publicationlastpage18
dc.identifier.publicationtitleAntioxidantsen
dc.identifier.publicationvolume12
dc.identifier.urihttps://hdl.handle.net/10016/38869
dc.identifier.uxxiAR/0000033511
dc.language.isoengen
dc.publisherMDPIen
dc.relation.projectIDGobierno de España. PID2021-128862OB-I00es
dc.relation.projectIDGobierno de España. PI17/01766. Grant BA21/00030es
dc.relation.projectIDComunidad de Madrid. PEJD-2018-PRE/BMD-7899es
dc.relation.projectIDComunidad de Madrid. PEJD-2017-TL/BMD-7385es
dc.relation.projectIDGobierno de España. PID2019-111510RB-I00es
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license https:// creativecommons.org/licenses/by/4.0/).en
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaMedicinaes
dc.subject.otherPoly I:Cen
dc.subject.otherSchizophreniaen
dc.subject.otherMicrobiota-gut-brain axisen
dc.subject.otherInflammationen
dc.subject.otherOxidative stressen
dc.titleMaternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophreniaen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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