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Sequential PET/CT with [F-18]-FDG predicts pathological tumor response to preoperative short course radiotherapy with delayed surgery in patients with locally advanced rectal cancer using logistic regression analysis

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dc.affiliation.dptoUC3M. Departamento de Economíaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Economía Política, Pública y del Bienestares
dc.contributor.authorPecori, Biagio
dc.contributor.authorLastoria, Secondo
dc.contributor.authorCaraco, Corradina
dc.contributor.authorCelentani, Marco
dc.contributor.authorTatangelo, Fabiana
dc.contributor.authorAvallone, Antonio
dc.contributor.authorRega, Daniela
dc.contributor.authorDe Palma, Giampaolo
dc.contributor.authorMormile, Maria
dc.contributor.authorBudillon, Alfredo
dc.contributor.authorMuto, Paolo
dc.contributor.authorBianco, Francesco
dc.contributor.authorAloj, Luigi
dc.contributor.authorPetrillo, Antonella
dc.contributor.authorDelrio, Paolo
dc.date.accessioned2023-10-06T07:55:01Z
dc.date.available2023-10-06T07:55:01Z
dc.date.issued2017-01-06
dc.description.abstractPrevious studies indicate that FDG PET/CT may predict pathological response in patients undergoing neoadjuvant chemo-radiotherapy for locally advanced rectal cancer (LARC). Aim of the current study is evaluate if pathological response can be similarly predicted in LARC patients after short course radiation therapy alone. Methods: Thirty-three patients with cT2-3, N0-2, M0 rectal adenocarcinoma treated with hypo fractionated short course neoadjuvant RT (5x5 Gy) with delayed surgery (SCRTDS) were prospectively studied. All patients underwent 3 PET/CT studies at baseline, 10 days from RT end (early), and 53 days from RT end (delayed). Maximal standardized uptake value (SUVmax), mean standardized uptake value (SUVmean) and total lesion glycolysis (TLG) of the primary tumor were measured and recorded at each PET/CT study. We use logistic regression analysis to aggregate different measures of metabolic response to predict the pathological response in the course of SCRTDS. Results: We provide straightforward formulas to classify response and estimate the probability of being a major responder (TRG1-2) or a complete responder (TRG1) for each individual. The formulas are based on the level of TLG at the early PET and on the overall proportional reduction of TLG between baseline and delayed PET studies. Conclusions: This study demonstrates that in the course of SCRTDS it is possible to estimate the probabilities of pathological tumor responses on the basis of PET/CT with FDG. Our formulas make it possible to assess the risks associated to LARC borne by a patient in the course of SCRTDS. These risk assessments can be balanced against other health risks associated with further treatments and can therefore be used to make informed therapy adjustments during SCRTDS.en
dc.description.sponsorshipThis study was partially supported by a Research Grant to AB from the Italian Ministry of Health (RF-2011-02346914). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extent15
dc.identifier.bibliographicCitationPecori B, Lastoria S, Caracò C, Celentani M, Tatangelo F, Avallone A, et al. (2017) Sequential PET/CT with [18F]-FDG Predicts Pathological Tumor Response to Preoperative Short Course Radiotherapy with Delayed Surgery in Patients with Locally Advanced Rectal Cancer Using Logistic Regression Analysis. PLoS ONE 12(1): e0169462en
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0169462
dc.identifier.issn1932-6203
dc.identifier.publicationfirstpage1
dc.identifier.publicationissue1, e0169462
dc.identifier.publicationlastpage15
dc.identifier.publicationtitlePLoS Oneen
dc.identifier.publicationvolume12
dc.identifier.urihttps://hdl.handle.net/10016/38561
dc.identifier.uxxiAR/0000019096
dc.language.isoengen
dc.publisherPLOSen
dc.rights© 2017 Pecori et al.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaEnergía Nucleares
dc.subject.ecienciaEstadísticaes
dc.subject.ecienciaFarmaciaes
dc.subject.ecienciaMedicinaes
dc.subject.ecienciaTelecomunicacioneses
dc.titleSequential PET/CT with [F-18]-FDG predicts pathological tumor response to preoperative short course radiotherapy with delayed surgery in patients with locally advanced rectal cancer using logistic regression analysisen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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