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Evolution on neutral networks accelerates the ticking rate of the molecular clock

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dc.affiliation.dptoUC3M. Departamento de Matemáticases
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Interdisciplinar de Sistemas Complejos (GISC)es
dc.contributor.authorManrubia, Susanna C.
dc.contributor.authorCuesta, José A.
dc.date.accessioned2015-04-07T10:51:18Z
dc.date.available2015-04-07T10:51:18Z
dc.date.issued2014-11-12
dc.description.abstractLarge sets of genotypes give rise to the same phenotype because phenotypic expression is highly redundant. Accordingly, a population can accept mutations without altering its phenotype, as long as they transform its genotype into another one on the same set. By linking every pair of genotypes that are mutually accessible through mutation, genotypes organize themselves into genotype networks (GN). These networks are known to be heterogeneous and assortative. As these features condition the probability that mutations keep the phenotype unchanged---hence becoming blind to natural selection---it follows that the topology of the GN will influence the evolutionary dynamics of the population. In this letter we analyze this effect by studying the dynamics of random walks (RW) on assortative networks with arbitrary topology. We find that the probability that a RW leaves the network is smaller the longer the time spent in it---i.e., the process is not Markovian. From the biological viewpoint, this "phenotypic entrapment" entails an acceleration in the fixation of neutral mutations, thus implying a non-uniform increase in the ticking rate of the molecular clock with the age of branches in phylogenetic trees. We also show that this effect is stronger the larger the fitness of the current phenotype relative to that of neighboring phenotypes.en
dc.description.sponsorshipThe authors acknowledge the Fnancial support of the Spanish Ministerio de Ciencia e Innovación under projects FIS2011-27569, PRODIEVO (FIS2011-22449), and Complexity-NET RESINEE, and of Comunidad de Madrid under project MODELICO-CM (S2009/ESP-1691).en
dc.format.extent5
dc.format.mimetypeapplication/pdf
dc.identifier.bibliographicCitationInterface, 12(102), (ID 20141010), Nov. 2014en
dc.identifier.doihttps://doi.org/10.1098/rsif.2014.1010
dc.identifier.issn1742-5689
dc.identifier.publicationfirstpage20141010
dc.identifier.publicationissue102
dc.identifier.publicationlastpage20141010
dc.identifier.publicationtitleJournal of The Royal Society Interfaceen
dc.identifier.publicationvolume12
dc.identifier.urihttps://hdl.handle.net/10016/20081
dc.identifier.uxxiAR/0000015335
dc.language.isoeng
dc.publisherThe Royal Societyen
dc.relation.hasversionhttps://arxiv.org/abs/1307.0968
dc.relation.isversionofEvolution on genotype networks leads to phenotypic entrapmenten
dc.relation.projectIDComunidad de Madrid. S2009/ESP-1691/MODELICOes
dc.relation.projectIDGobierno de España. FIS2011-22449/PRODIEVO
dc.relation.projectIDGobierno de España. FIS2011–27569
dc.rights© 2014 The Author(s) Published by the Royal Society. All rights reserved.en
dc.rights.accessRightsopen access
dc.subject.ecienciaMatemáticases
dc.subject.otherPopulations and Evolutionen
dc.subject.otherStatistical Mechanicsen
dc.subject.otherAssortative networksen
dc.subject.otherMutation accumulationen
dc.titleEvolution on neutral networks accelerates the ticking rate of the molecular clocken
dc.typeresearch article*
dc.type.hasVersionSMUR*
dspace.entity.typePublication
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