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Validation of a restrospective respiratory gating method for small-animal CT scanners

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Groupes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédicaes
dc.contributor.authorChavarrías, Cristina
dc.contributor.authorVaquero López, Juan José
dc.contributor.authorSisniega, Alejandro
dc.contributor.authorRodríguez Ruano, Alexia
dc.contributor.authorSoto Montenegro, Mª Luisa
dc.contributor.authorDesco Menéndez, Manuel
dc.date.accessioned2011-09-28T15:13:19Z
dc.date.available2011-09-28T15:13:19Z
dc.date.issued2008-10
dc.descriptionProceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 October 2008
dc.description.abstractWe propose a retrospective respiratory gating algorithm to generate dynamic CT studies. To this end, we compared three different methods of extracting the respiratory signal from the projections of small-animal cone-beam computed tomography (CBCT) scanners. Given a set of frames acquired from a certain axial angle, subtraction of their average image from each individual frame produces a set of difference images. The respiratory signals were extracted by analyzing the shape of the histogram of these difference images: we calculated the first four central and non-central moments. However, only odd-order moments produced the desired breathing signal, as the even-order moments lacked information about the phase. Each of these curves was compared to a reference signal recorded by means of a pneumatic pillow. Given the similar correlation coefficients yielded by all of them, we selected the mean to implement our retrospective protocol. Respiratory phase bins were separated, reconstructed independently and included in a dynamic sequence, suitable for cine playback. We validated our method in 5 adult rat studies by comparing profiles drawn across the diaphragm dome, with and without retrospective respiratory gating. Results showed a sharper transition in the gated reconstruction, with an average slope improvement of 60.7%.
dc.description.sponsorshipThis project was supported by the CENIT Programme (Ministerio de Industria), CIBER CB07/09/0031 and RETICRECAVA (Ministerio de Sanidad y Consumo), and TEC2007-64731 TCM (Ministerio de Educaci6n y Ciencia).
dc.format.mimetypeapplication/pdf
dc.identifier.bibliographicCitation2008 IEEE Nuclear Science Symposium Conference Record, oct. 2008, p. 4303 - 4305
dc.identifier.doi10.1109/NSSMIC.2008.4774235
dc.identifier.isbn978-1-4244-2714-7
dc.identifier.issn1082-3654
dc.identifier.publicationfirstpage4303
dc.identifier.publicationlastpage4305
dc.identifier.publicationtitle2008 IEEE Nuclear Science Symposium Conference Record
dc.identifier.urihttps://hdl.handle.net/10016/12200
dc.language.isoeng
dc.publisherIEEE
dc.relation.eventdateOctober 19-25, 2008
dc.relation.eventplaceDresden, Germany
dc.relation.eventtitle2008 IEEE Nuclear Science Symposium Conference Record (NSS '08)
dc.relation.publisherversionhttp://dx.doi.org/10.1109/NSSMIC.2008.4774235
dc.rights© IEEE
dc.rights.accessRightsopen access
dc.subject.ecienciaBiología y Biomedicina
dc.titleValidation of a restrospective respiratory gating method for small-animal CT scanners
dc.typeconference paper*
dspace.entity.typePublication
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