Publication:
Strategies to Control in Vitro Degradation of Mg Scaffolds Processed by Powder Metallurgy

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dc.affiliation.dptoUC3M. Departamento de Ciencia e Ingeniería de Materiales e Ingeniería Químicaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Tecnología de Polvoses
dc.contributor.authorCifuentes Cuéllar, Sandra Carolina
dc.contributor.authorAlvarez, Lucia
dc.contributor.authorArias Arias, Luis Andres
dc.contributor.authorFey, Tobias
dc.contributor.authorTsipas, Sophia Alexandra
dc.contributor.funderComunidad de Madrides
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es
dc.date.accessioned2023-04-18T16:23:36Z
dc.date.available2023-04-18T16:23:36Z
dc.date.issued2022-04-01
dc.description.abstractMagnesium scaffolds are biodegradable, biocompatible, bioactive porous scaffolds, which find applications within tissue engineering. The presence of porosity increases surface area and enhances cell proliferation and tissue ingrowth. These characteristics make Mg scaffolds key materials to enhance the healing processes of tissues such as cartilage and bone. However, along with the increment of porosity, the corrosion of magnesium within a physiological environment occurs faster. It is, therefore, necessary to control the degradation rate of Mg scaffolds in order to maintain their mechanical properties during the healing process. Several studies have been performed to increase Mg scaffolds' corrosion resistance. The different approaches include the modification of the Mg surface by conversion coatings or deposited coatings. The nature of the coatings varies from ceramics such as hydroxyapatite and calcium phosphates to polymers such as polycaprolactone or gelatin. In this work, we propose a novel approach to generating a protective bilayer coating on the Mg scaffold surface composed of a first layer of naturally occurring Mg corrosion products (hydroxide and phosphates) and a second layer of a homogeneous and biocompatible coating of polylactic acid. The Mg scaffolds were fabricated from Mg powder by means of powder metallurgy using ammonium bicarbonate as a space holder. The size and amount of porosity were controlled using different size distributions of space holders. We addressed the influence of scaffold pore size on the conversion and deposition processes and how the coating process influences the in vitro degradation of the scaffolds.en
dc.description.sponsorshipThe authors would like to thank the funding provided for this research by the Regional Government of Madrid (Dra. Gral. Universidades e Investigación) through the project P2018/NMT4411 (ADITIMAT-CM) and the Spanish Government through the projects PID2019-106631GB-C43 and RTC2019-007049-4.en
dc.description.statusPublicadoes
dc.format.extent17es
dc.identifier.bibliographicCitationCifuentes, S.C., et al. Strategies to Control In Vitro Degradation of Mg Scaffolds Processed by Powder Metallurgy. In: Metals 2022, 12, 566, (17 p.)en
dc.identifier.doihttps://doi.org/10.3390/met12040566
dc.identifier.issn2075-4701
dc.identifier.publicationissue4
dc.identifier.publicationtitleMetalsen
dc.identifier.publicationvolume12, 566
dc.identifier.urihttps://hdl.handle.net/10016/37128
dc.identifier.uxxiAR/0000031282
dc.language.isoengen
dc.publisherMDPIen
dc.relation.projectIDGobierno de España. PID2019-106631GB-C43es
dc.relation.projectIDGobierno de España. RTC2019-007049-4es
dc.relation.projectIDComunidad de Madrid. P2018/NMT-4411/ADITIMAT-CMes
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland.en
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) licenseen
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Españaen
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.ecienciaIngeniería Industrialen
dc.subject.ecienciaQuímicaen
dc.subject.otherBiodegradableen
dc.subject.otherIn Vitro Degradationen
dc.subject.otherMg Scaffoldsen
dc.subject.otherPowder Metallurgyen
dc.titleStrategies to Control in Vitro Degradation of Mg Scaffolds Processed by Powder Metallurgyen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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