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Relevance of cannabinoids in preclinical models of psychiatric disorders

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dc.contributor.advisorSoto Montenegro, Mª Luisa
dc.contributor.authorLamanna Rama, Nicolás
dc.contributor.departamentoUC3M. Departamento de Bioingenieríaes
dc.contributor.tutorDesco Menéndez, Manuel
dc.date.accessioned2023-10-27T11:33:26Z
dc.date.available2023-10-27T11:33:26Z
dc.date.issued2023-09
dc.date.submitted2023-09-28
dc.description.abstractThroughout this thesis, we are going to navigate through the history of cannabis, from its first use thousands of years ago, to its exponential growth in use and knowledge during the last third of the last century. The endocannabinoid system was a cutting-edge discovery, which initiated interest in cannabinoids both in their effects on the human body, and in their interaction with other neural systems, such as the dopaminergic reward system. Not much later, the implications of cannabis in adolescence were postulated, opening a wide range of possibilities in the study of cannabinoids. Consequently, researchers began to wonder whether cannabinoids might influence the consumption of other drugs and, the possible interactions with other endogenous systems, such as the opioid system, and their association with the onset of psychiatric disorders, such as schizophrenia. In this sense, preclinical models have provided a great impulse for the understanding of such processes and effects of cannabinoids. Nevertheless, it is important to note that the field of cannabinoid research is rapidly evolving, and although substantial progress has been made, many questions remain to be answered.en
dc.description.degreePrograma de Doctorado en Ciencia y Tecnología Biomédica por la Universidad Carlos III de Madrides
dc.description.responsabilityPresidente: Juan Nàcher Roselló.- Secretaria: Raquel Abalo Delgado.- Vocal: Miguel Ángel Morcillo Alonsoes
dc.identifier.urihttps://hdl.handle.net/10016/38697
dc.language.isoengen
dc.relation.hasparthttps://doi.org/10.1016/j.euroneuro.2023.01.005
dc.relation.hasparthttps://doi.org/10.1038/s41598-022-08698-9
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaMedicinaes
dc.subject.otherBrainen
dc.subject.otherAdictionsen
dc.subject.otherMetabolismen
dc.subject.otherGlucoseen
dc.subject.otherDrugs withdrawalen
dc.subject.otherNeuroimagingen
dc.subject.otherPositron emission tomographyen
dc.subject.otherX-Ray computed tomographyen
dc.titleRelevance of cannabinoids in preclinical models of psychiatric disordersen
dc.typedoctoral thesis*
dspace.entity.typePublication
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