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Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.contributor.authorCasquero Veiga, Marta
dc.contributor.authorGarcía García, David
dc.contributor.authorDesco Menéndez, Manuel
dc.contributor.authorSoto Montenegro, Mª Luisa
dc.contributor.funderMinisterio de Economía y Competitividad (España)es
dc.date.accessioned2023-11-10T13:36:24Z
dc.date.available2023-11-10T13:36:24Z
dc.date.issued2018-10-17
dc.description.abstractDeep brain stimulation (DBS) is a neurosurgery technique widely used in movement disorders, although its mechanism of action remains unclear. In fact, apart from the stimulation itself, the mechanical insertion of the electrode may play a crucial role. Here we aimed to distinguish between the insertional and the DBS effects on brain glucose metabolism. To this end, electrodes were implanted targeting the medial prefrontal cortex in five adult male Wistar rats. Positron Emission Tomography (PET) studies were performed before surgery (D0) and seven (D7) and nine days (D9) after that. DBS was applied during the (18)FDG uptake of the D9 study. PET data were analysed with statistical parametric mapping. We found an electrode insertional effect in cortical areas, while DBS resulted in a more widespread metabolic pattern. The consequences of simultaneous electrode and DBS factors revealed a combination of both effects. Therefore, the insertion metabolic effects differed from the stimulation ones, which should be considered when assessing DBS protocols.es
dc.format.mimetypeapplication/pdfen
dc.identifier.bibliographicCitationCasquero-Veiga, M., García-García, D., Desco, M., & Soto-Montenegro, M. L. (2018). Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect. BioMed Research International 2018, pp. 1-6.es
dc.identifier.doi10.1155/2018/8560232
dc.identifier.issn2314-6133
dc.identifier.publicationfirstpage8560232-1es
dc.identifier.publicationlastpage8560232-6es
dc.identifier.publicationtitleBiomed Research Internationalen
dc.identifier.publicationvolume2018es
dc.identifier.urihttps://hdl.handle.net/10016/38829
dc.identifier.uxxiAR/0000022661
dc.language.isoengen
dc.publisherHindawien
dc.relation.projectIDGobierno de España. [PI14/00860, CPII14/00005 y PI17/01766]es
dc.relation.projectIDComunidad de Madrid. [BRADE-CM S2013/ICE-2958].es
dc.rights© 2018 Marta Casquero-Veiga et al.en
dc.rightsAtribución 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.ecienciaMedicinaes
dc.subject.otherPatternsen
dc.subject.otherCortexen
dc.subject.otherTargeten
dc.titleUnderstanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effecten
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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