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Statistical theory of phenotype abundance distributions: A test through exact enumeration of genotype spaces

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dc.affiliation.dptoUC3M. Departamento de Matemáticases
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Interdisciplinar de Sistemas Complejos (GISC)es
dc.contributor.authorGarcía Martín, Juan Antonio
dc.contributor.authorCatalan, Pablo
dc.contributor.authorManrubia, Susanna
dc.contributor.authorCuesta, José A.
dc.contributor.funderEuropean Commissionen
dc.contributor.funderMinisterio de Economía y Competitividad (España)es
dc.date.accessioned2019-11-20T10:49:14Z
dc.date.available2019-11-20T10:49:14Z
dc.date.issued2018-08
dc.description.abstractThe evolutionary dynamics of molecular populations are strongly dependent on the structure of genotype spaces. The map between genotype and phenotype determines how easily genotype spaces can be navigated and the accessibility of evolutionary innovations. In particular, the size of neutral networks corresponding to specific phenotypes and its statistical counterpart, the distribution of phenotype abundance, have been studied through multiple computationally tractable genotype-phenotype maps. In this work, we test a theory that predicts the abundance of a phenotype and the corresponding asymptotic distribution (given the compositional variability of its genotypes) through the exact enumeration of several GP maps. Our theory predicts with high accuracy phenotype abundance, and our results show that, in navigable genotype spaces-characterised by the presence of large neutral networks- phenotype abundance converges to a log-normal distribution.en
dc.description.sponsorshipK. Dingle, E. Ferrada, Ch. Holzgrafe, A. Irback and A. Louis are gratefully thanked for sharing their data with us. We acknowledge financial support by the Spanish Ministerio de Economía y Competitividad and FEDER funds of the EU through grants VARIANCE (FIS2015-64349-P) (P.C. and J.A.C.) and ViralESS (FIS2014-57686-P) (J.A.G.M. and S.M.).en
dc.format.extent7
dc.identifier.bibliographicCitationGarcía-Martín, J.A., Catalán, P., Manrubia, S. y Cuesta, J.A. (2018). Statistical theory of phenotype abundance distributions: a test through exact enumeration of genotype spaces. EPL (Europhysics Letters),123(2).en
dc.identifier.doihttps://doi.org/10.1209/0295-5075/123/28001
dc.identifier.issn0295-5075
dc.identifier.publicationissue2 (28001)
dc.identifier.publicationtitleEPL (Europhysics Letters)en
dc.identifier.publicationvolume123
dc.identifier.urihttps://hdl.handle.net/10016/29200
dc.identifier.uxxiAR/0000021970
dc.language.isoengen
dc.publisherIOP Publishingen
dc.relation.projectIDGobierno de España. FIS2015-64349-Pes
dc.relation.projectIDGobierno de España. FIS2014-57686-Pes
dc.rights© 2018 EPLA.en
dc.rights.accessRightsopen accessen
dc.subject.ecienciaMatemáticases
dc.titleStatistical theory of phenotype abundance distributions: A test through exact enumeration of genotype spacesen
dc.typeresearch article*
dc.type.hasVersionAM*
dspace.entity.typePublication
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