Publication: A model for the oscillatory flow in the cerebral aqueduct
Loading...
Identifiers
Publication date
2020-07-20
Defense date
Advisors
Tutors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
This paper addresses the pulsating motion of cerebrospinal fluid in the aqueduct of
Sylvius, a slender canal connecting the third and fourth ventricles of the brain. Specific
attention is given to the relation between the instantaneous values of the flow rate and
the interventricular pressure difference, needed in clinical applications to enable indirect
evaluations of the latter from direct magnetic resonance measurements of the former.
An order of magnitude analysis accounting for the slenderness of the canal is used
in simplifying the flow description. The boundary layer approximation is found to be
applicable in the slender canal, where the oscillating flow is characterized by stroke lengths
comparable to the canal length and periods comparable to the transverse diffusion time. By
way of contrast, the flow in the non-slender opening regions connecting the aqueduct with
the two ventricles is found to be inviscid and quasi-steady in the first approximation. The
resulting simplified description is validated by comparison with results of direct numerical
simulations. The model is used to investigate the relation between the interventricular
pressure and the stroke length, in parametric ranges of interest in clinical applications.
Description
Keywords
Biomedical flows
Bibliographic citation
Sincomb, S., Coenen, W., Sánchez, A. L., & Lasheras, J. C. (2020). A model for the oscillatory flow in the cerebral aqueduct. Journal of Fluid Mechanics, 899.